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1321 articles
October 202624
Zamtocabtagene autoleucel, a tandem CD20-CD19-directed CAR T-cell therapy, for second line treatment of large B-cell lymphoma in patients ineligible for transplantation (DALY 2-EU): primary analysis of an open-label, multicentre, randomised phase 2 study.
DALY 2-EU was an open-label, multicentre, randomised phase 2 trial comparing tandem CD20-CD19-directed zamtocabtagene autoleucel (zamto-cel) with R-GemOx in adults with second-line relapsed or refractory large B-cell…
Effects of Whey Protein Supplementation on Muscle Damage, Hepatic Stress, and Inflammatory Markers in Power- and Endurance-Trained Athletes.
This randomized, double-blind, placebo-controlled trial examined 8 weeks of whey protein supplementation (30 g/day) in 59 male power- and endurance-trained athletes.
Combining Cognitive Training and Brain Stimulation: A Novel Approach to Address Disordered Eating and Antipsychotic-Induced Weight Gain in People With Severe Mental Illness.
This double-blind, parallel-group, sham-controlled randomised trial assessed the feasibility of combining Approach Bias Modification Training (ABMT) with real or sham transcranial direct current stimulation (tDCS) in…
Rare and Novel Hepatitis C Virus Genotype Subtypes and Response to Sofosbuvir/Velpatasvir in A5360 (MINMON) Clinical Trial.
This analysis of samples from the multicountry ACTG A5360 (MINMON) clinical trial characterized rare and novel hepatitis C virus (HCV) subtypes and assessed baseline resistance-associated substitutions and response to…
Haemodynamic and Respiratory Effects of Dexmedetomidine as an Adjuvant to Oxycodone Patient-Controlled Analgesia After Lumbar Spinal Fusion: A Post Hoc Analysis of the DoseRespDex Randomised Controlled Trial.
This post hoc analysis of a randomised, double-blind, placebo-controlled trial examined haemodynamic and respiratory effects of dexmedetomidine added to oxycodone patient-controlled analgesia in 98 adults undergoing…
Efficacy and Safety of Apixaban Thromboprophylaxis According to Baseline Chemotherapy Class in High-Risk Ambulatory Cancer Patients: A Post Hoc Analysis of the AVERT Trial.
This post hoc analysis of the randomized, double-blind AVERT trial examined apixaban thromboprophylaxis by baseline chemotherapy class in 563 ambulatory patients with cancer starting chemotherapy.
Four weeks of isometric handgrip training results in lower awake ambulatory blood pressure compared with control: a randomized clinical trial.
This randomized controlled trial compared handgrip and knee-extension isometric training with control in 67 adults with controlled hypertension receiving antihypertensive medication.
Evaluating gain and loss-framed mobile messaging to improve maternal health service uptake: A cluster randomized controlled trial in Jimma, Ethiopia.
This three-arm cluster-randomized controlled trial assessed whether gain- or loss-framed SMS messaging improved maternal health service use among 588 pregnant women in Jimma Zone, Ethiopia.
The association between e-cigarette use and dyslipidemia: A systematic review and meta-analysis of observational studies.
This systematic review and meta-analysis examined observational evidence on exclusive e-cigarette use and blood lipids in adults. Seven studies from four countries included 25,690 participants.
Dose-Response Effects of Exercise Training on Circulating Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-analysis of Randomised Controlled Trials.
This systematic review and meta-analysis pooled randomised controlled trials comparing chronic exercise with non-exercising controls to assess circulating brain-derived neurotrophic factor (BDNF).
Local Delivery of Interferon-β1a for Respiratory Viral Infections: A Systematic Review.
This PRISMA-guided systematic review assessed locally delivered intranasal or inhaled interferon-β1a for respiratory viral infections, covering clinical trials and experimental evidence.
A Short Evidence-Based, Belief-Focused Educational Video Improves Back Pain Beliefs but Not Lifting Behaviour in Healthy Office Workers: An Exploratory Randomised Controlled Trial.
This assessor-blind exploratory randomised controlled trial assigned 50 healthy office workers to a brief video about back pain beliefs and management or an anatomy-video control.
A systematic review of the spectrum of magnetic resonance imaging features of degenerative thoracic myelopathy.
This PRISMA-guided systematic review synthesised evidence on MRI features of degenerative thoracic myelopathy (DTM) and their clinical significance.
Imaging Features and Prognosis of Anti‑Sez6l2 Encephalitis: A Longitudinal Cohort Study and Literature Review.
This longitudinal cohort study and systematic review examined clinical features, multimodal imaging, and treatment response in anti-Sez6l2 encephalitis.
Does the "switch the plane" strategy improve outcomes? Anterior vs. posterior repair for recurrence after prior inguinal hernia repair: a systematic review and meta-analysis.
This systematic review and meta-analysis examined outcomes of recurrent unilateral inguinal hernia repair by operative plane, including comparative studies of posterior versus repeat anterior repair after prior anterior…
Effectiveness of Exercise Snacks in Mitigating Adolescent Problematic Smartphone Use: A Four-Wave Cluster Randomized Controlled Trial.
This four-wave cluster randomized controlled trial tested whether brief, vigorous activity breaks could reduce problematic smartphone use among 386 adolescents in 12 secondary-school classes.
From Bench to Bedside: Evaluating the Accuracy of Clinical Sensory Testing in Detecting Somatosensory Disorders. A Systematic Review.
This systematic review assessed the diagnostic accuracy of clinical sensory tests (CSTs) for somatosensory disorders across populations and conditions, comparing test results with reference standards.
Interleukin-6 and C-reactive protein prognostic value following acute coronary syndrome.
This post hoc prognostic analysis of the multicentre ODYSSEY OUTCOMES randomised trial examined hsCRP and IL-6 in 11,817 patients with recent acute coronary syndrome.
An Individual Meta-Analysis of Psychological Treatments for Mood and Personality Disorders Using the Severity Diagnostic System of ICD-11.
This individual patient meta-analysis examined whether ICD-11 personality-disorder severity was associated with short-term outcomes in 1,384 patients from four randomised trials of psychological treatments, mainly…
Efficacy and safety study of diclofenac epolamine topical patch in accelerating rehabilitation of moderate hamstring strain: A randomized controlled trial .
This single-centre, double-blind, placebo-controlled randomised trial evaluated topical diclofenac epolamine alongside rehabilitation in 120 patients with moderate hamstring strain.
Association of Screen Time With Physical and Mental Health in University Students: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined screen-time duration and physical and mental health outcomes in university students aged 17 years or older.
Crisis Interventions for Children and Adolescents with Depression and Suicidality: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined crisis services for children and adolescents experiencing acute mental health crises, including severe depression, suicidal ideation, self-harm, and suicidal behaviour.
Safety and Effectiveness of a Novel Laser-Based Intravascular Lithotripsy System for Coronary Calcium: FRACTURE Study.
FRACTURE was a prospective, multicenter, single-arm clinical trial evaluating a laser- and optic-based quad-emitter intravascular lithotripsy system in patients with severely calcified de novo coronary lesions.
Music-based interventions for people with kidney failure undergoing haemodialysis.
This Cochrane systematic review and meta-analysis assessed randomised trials of music-based interventions in people with kidney failure receiving haemodialysis.
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