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1313 articles
October 202624
The Effects of Force-Velocity Profile-Based Load Prescription on Muscle Power and Functional Performance in Velocity-Deficient Older Adults.
This 12-week randomized controlled trial compared force–velocity profile-guided resistance-training loads in adults aged 65 years or older with a velocity deficit.
Sexual dimorphism and age effects in CKD and type 2 diabetes in the CONFIDENCE trial.
This analysis of the randomized CONFIDENCE trial examined age- and sex-related differences in urinary albumin-to-creatinine ratio (UACR) changes among people with type 2 diabetes and chronic kidney disease receiving…
Acute declines in kidney function with thiazide plus loop diuretics versus loop diuretics alone in acute decompensated heart failure.
This analysis of the randomized CLOROTIC trial examined whether early eGFR changes were associated with outcomes in patients admitted with acute decompensated heart failure and randomized to thiazide or placebo…
Heterogeneity in Depression and Suicidality Risk Among Vitiligo Patients: A Meta-Analysis of Adolescent Complexity and Subgroup Stratification.
This meta-analysis assessed depression and suicidality in people with vitiligo, drawing on 73 studies identified through searches of four databases. The pooled prevalence of depression was 0.37 (95% CI, 0.30-0.45).
Prone positioning and high-frequency oscillatory ventilation in early paediatric acute respiratory distress syndrome (PROSpect): an international, two-by-two factorial, response-adaptive, phase 3, randomised controlled trial.
PROSpect was an international, two-by-two factorial, phase 3 randomised controlled trial comparing prone with supine positioning and high-frequency oscillatory ventilation (HFOV) with conventional mechanical ventilation…
The Effects of Virtual Reality Group Reminiscence Therapy on Agitation, Cognition, Depression and Social Function in Patients With Alzheimer's Disease.
This assessor-blinded randomised controlled trial evaluated multisensory virtual reality group reminiscence therapy in 60 people with Alzheimer’s disease, comparing twice-weekly 40-minute sessions for 8 weeks with…
The Effect of Bupropion in Peripheral Neuropathic Pain A Randomized, Double-Blind, Placebo-Controlled Study.
This randomized, double-blind, placebo-controlled crossover study assessed bupropion for peripheral neuropathic pain and whether response varied with conditioned pain modulation (CPM) or sensory phenotype.
Post-transplant follow-up for kidney transplant recipients: a systematic review of clinical practice guidelines.
This systematic review compared clinical practice guidelines for post-transplant follow-up of kidney transplant recipients, assessing methodological quality and recommendations for surveillance.
Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease.
This prospective, parallel-group randomized controlled trial assessed a 12-week telehealth-supported home exercise program in adults aged ≥45 years with non-dialysis stage 4-5 chronic kidney disease.
Incidence of Intensive Care Unit Delirium After Heart Surgery: A Feasibility Study of a Forest Environment Intervention.
This randomized feasibility study evaluated forest-environment and light-exposure interventions, compared with standard care, in adults undergoing elective cardiac surgery at a tertiary ICU in Austria.
Decitabine plus busulfan-cyclophosphamide versus busulfan-cyclophosphamide myeloablative conditioning before allogeneic haematopoietic stem cell transplantation for reducing risk of relapse in adult KMT2A‑rearranged leukaemia in China: an open-label, multicentre, randomised phase 3 trial.
This open-label, multicentre, randomised phase 3 trial compared decitabine plus busulfan-cyclophosphamide (DAC-BuCy) with BuCy conditioning before allogeneic HSCT in 130 patients aged 14–65 years with KMT2A-rearranged…
First-in-Human Phase 1b/2a Trial Shows Safety with MEK 1/2 Inhibitor EDV2209 as A Novel Treatment for Spontaneous Subarachnoid Hemorrhage.
The STOP-DCI first-in-human Phase 1b/2a interventional, randomized, double-blind, placebo-controlled trial evaluated intracerebroventricular EDV2209, a MEK 1/2 inhibitor, in patients with severe spontaneous subarachnoid…
Between Skin and Brain: A Systematic Review of 712 Cases 1976-2025 Reveals a Highly Diverse Disease Spectrum in Chaetothyriales.
This systematic review examined the global epidemiology, causative species, clinical presentations, and outcomes of 712 reported Chaetothyriales infections from 1976 to 2025.
Reducing Central Line-Associated Bloodstream Infections in ICUs: A Systematic Review of Barriers and Facilitators and Intervention Measures.
This PRISMA-guided systematic review examined barriers and facilitators to implementing central line-associated bloodstream infection (CLABSI) prevention among ICU healthcare workers.
Artificial Intelligence-Enabled Electrocardiogram Screening for Detection of Low Ejection Fraction in Routine Care: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis evaluated randomised controlled trials of AI-enabled ECG screening for low ejection fraction in adults without known heart failure undergoing routine ECGs.
Phase 1 Study of Safety and PK With A Combination of Omeprazole and Trimetazidine for Fatty Acid Oxidation Inhibition in Patients With Advanced Solid Tumors.
This Phase I, open-label, 3 + 3 dose-escalation study assessed safety, tolerability, pharmacokinetics, and preliminary antitumor activity of once-daily oral omeprazole plus trimetazidine, two fatty acid oxidation…
Effectiveness of Tomazoni Measurement Method for Central Catheter Tip Positioning in Neonates: A Randomised Controlled Trial.
This pragmatic, parallel-group randomised controlled trial compared the Tomazoni and traditional measurement methods for positioning peripherally inserted central catheter (PICC) tips in neonates at a Brazilian neonatal…
Virtual Social Interaction and Psychological Capital in Chemotherapy Patients: A Randomized Controlled Trial.
This single-blind randomized controlled trial evaluated a six-week virtual social interaction program for 76 patients receiving chemotherapy at one Iranian hospital.
Survival Outcomes in Metastatic Colorectal Cancer Patients with BRAF Mutations Undergoing Targeted Chemotherapy: A Reconstructed Individual Patient Data Meta-Analysis of Randomized Controlled Trials.
This reconstructed individual patient-data meta-analysis of 18 randomized controlled trials examined survival outcomes across targeted treatment classes in BRAF V600E-mutant metastatic colorectal cancer.
Association of Helicobacter pylori eradication with proteinuria reduction and kidney outcomes: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed whether Helicobacter pylori eradication is associated with renal benefits in people with kidney disease or proteinuria.
Polycystic ovary syndrome research in sub-Saharan Africa: a systematic review on current status and future directions.
This systematic review assessed original research on polycystic ovary syndrome (PCOS) in sub-Saharan African populations, searching four databases through 9 August 2026.
Prehospital Analgesia in Trauma: A Systematic Review of Current Evidence.
This systematic review assessed the safety and effectiveness of pharmacologic analgesia given before hospital arrival to acutely injured adults aged over 15 years.
Robot-assisted minimally invasive versus conventional open transforaminal lumbar interbody fusion for lumbar degenerative disease: a prospective randomized controlled trial.
This prospective, single-centre, assessor-blinded randomized trial compared robot-assisted minimally invasive TLIF with conventional fluoroscopy-guided open TLIF in 128 patients with lumbar degenerative disease.
The Effects of Mind-Body Exercise on Cognitive Function and Peripheral Blood BDNF in Elderly People With Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled 17 randomized controlled trials involving 1,251 older adults with mild cognitive impairment to assess mind-body exercise and cognition and peripheral blood BDNF.
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