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1022 articles
August 202622
Clinical Profile, Electrophysiology, and Short-Term Outcomes of Pediatric-Onset Autoimmune Nodopathy-A Case Series.
The report describes three children with autoimmune nodopathy associated with antibodies to neurofascin 140, alone or with neurofascin 186.
Efficacy and tolerability of mirogabalin, pregabalin, duloxetine, and placebo in patients with type 2 diabetes mellitus and painful diabetic peripheral neuropathy: A network meta-analysis.
This network meta-analysis evaluated the efficacy and tolerability of mirogabalin, pregabalin, and duloxetine in treating painful diabetic peripheral neuropathy (PDPN) in patients with type 2 diabetes mellitus (T2DM).
Effects of brain-computer interface-based training on post-stroke lower limb rehabilitation: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of brain-computer interface (BCI) training on lower-limb rehabilitation post-stroke, analyzing ten randomized controlled trials with 366 participants.
Sigma-1 Receptor Ligand Blarcamesine (ANAVEX 2-73) for Alzheimer's Disease: A Systematic Review.
This systematic review evaluated the efficacy and safety of blarcamesine (ANAVEX 2-73) in early-stage and mild-to-moderate Alzheimer's disease (AD).
Blue light therapy delivered through light glasses improves sleep quality and daytime sleepiness in Parkinson's disease: A randomized trial.
This randomized controlled trial evaluated the effects of blue light therapy delivered through glasses on sleep quality and daytime sleepiness in individuals with Parkinson's disease.
Covert consciousness in behavioral coma.
An 80-year-old woman with acute severe traumatic brain injury presented with behavioral evidence of coma. Comprehensive evaluations using task-based fMRI and EEG revealed covert consciousness, indicating she could…
Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage: A Placebo-Controlled Trial.
This pilot randomized controlled trial evaluated the feasibility of colchicine for preventing vascular events after acute intracerebral hemorrhage (ICH) in adults with vascular risk factors.
A De Novo DHX16 Variant Associated With Neuromuscular Oculoauditory Syndrome Regulates Pre-mRNA Splicing In Vitro.
Neuromuscular oculoauditory syndrome (NMOAS; OMIM# 618733) is a rare neurodevelopmental disorder caused by heterozygous variants in DHX16, a gene in the DExD/H-box RNA helicase family.
Pediatric Cluster Headache Beyond Diagnostic Criteria: A Case Series and Review of Treatment Response.
The report describes four children—three boys and one girl—diagnosed with cluster headache, a disorder characterized by brief, unilateral pain around the eye with autonomic symptoms.
Dose-Controlled Script Training for Aphasia: A Quasi-Randomized Pilot Clinical Trial Examining Treatment Frequency.
This quasi-randomized pilot clinical trial investigated the impact of treatment frequency on outcomes in 45 adults with chronic poststroke aphasia.
Therapeutic local hypothermia in the management of acute spinal cord injury: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the safety and efficacy of local hypothermia in treating acute spinal cord injury (ASCI) across five studies involving 48 patients.
Trametinib-mediated MEK inhibition impairs cancer cell viability and invasion in patient-derived tumor avatars of glioblastoma with extraneural metastases: A proof-of-concept study.
A patient with glioblastoma (GBM) presented with rare extraneural metastases, characterized by aggressive molecular features including alterations in NF1, TP53, PTEN, and RB1.
High-frequency contralesional dorsal premotor cortex and low-frequency contralesional primary motor cortex rTMS in subacute stroke with severe upper limb impairment: comparable motor outcomes and differential regional degree centrality changes.
This randomized controlled trial evaluated the effects of high-frequency rTMS over the contralesional dorsal premotor cortex versus low-frequency rTMS over the contralesional primary motor cortex in 46 patients with…
Primary central nervous system T cell lymphoma involving multiple brain and spinal cord lesions with SETD2 mutation.
A 37-year-old Japanese man presented with impaired consciousness, and imaging revealed multiple contrast-enhancing lesions in the brain and spinal cord.
Guidelines for Seizure Prophylaxis in Patients with Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society.
This systematic review and meta-analysis informed Neurocritical Care Society guidance on antiseizure medication (ASM) prophylaxis in adults hospitalized with aneurysmal subarachnoid hemorrhage (SAH) and without prior…
Bispecific Antibodies Are Associated With Progressive Multifocal Leukoencephalopathy.
This report details five patients with relapsed and refractory multiple myeloma who developed progressive multifocal leukoencephalopathy (PML following treatment with bispecific antibodies.
Quantitative susceptibility mapping in neurodegenerative diseases: An umbrella review of iron-related biomarkers and mechanisms.
This umbrella review evaluates the role of quantitative susceptibility mapping (QSM) in assessing iron-related biomarkers across various neurodegenerative diseases (NDDs), including Parkinson's disease, Alzheimer's…
Cognitive-metabolic relationship in temporal lobe epilepsy: A systematic review.
This systematic review examined the relationship between neurometabolic dysfunction and cognitive impairment in 1161 patients with temporal lobe epilepsy (TLE).
The acute effects of a single session of intermittent hypoxia on blood biomarker concentrations and sleep parameters in people with Parkinson's disease: A randomized, double-blind, crossover trial.
This randomized, double-blind, crossover trial examined acute and 24-hour effects of one intermittent hypoxia (IH) session on sleep and blood biomarkers in 15 people with Parkinson’s disease (pwPD) and 15 sex-matched…
Chorea-Acanthocytosis Without Acanthocytosis: Sensory Neuronopathy and Epilepsy as Prominent Features From a Novel VPS13A Variant.
A 29-year-old woman with a novel homozygous VPS13A variant presented with drug-resistant temporal-lobe epilepsy and severe sensory neuronopathy.
A fatal ascending spinal subdural empyema due to Streptococcus intermedius in a socially vulnerable patient: Forensic perspectives on diagnostic delay and implicit bias.
A 63-year-old man with a history of repeated emergency department visits presented with persistent lower back pain and neurological symptoms.
Efficacy and safety of cannabinoids in the treatment of spasticity in multiple sclerosis: A systematic review of randomized clinical trials.
This systematic review evaluated the efficacy and safety of cannabinoids for treating spasticity in multiple sclerosis, analyzing 27 randomized controlled trials with over 3000 participants.
July 20262
Early antihypertensive therapy in acute ischemic stroke: A Meta-analysis of randomized controlled trials.
This meta-analysis evaluated the effects of early antihypertensive therapy (AHT) in 15,521 patients with acute ischemic stroke (AIS) across seven randomized controlled trials.
Modulation of heart rate and heart rate variability during animal-assisted treatment of patients in a minimally conscious state: A randomized controlled crossover study.
This randomized controlled crossover study examined the effects of animal-assisted treatment (AATx) on heart rate (HR) and heart rate variability (HRV) in 21 patients with minimally conscious state (MCS).
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