Trending archive
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1821 articles
September 202624
CAR T-cell therapy as a definitive consolidation for older adults with B-ALL in first complete remission.
This phase 1 clinical trial evaluated the safety and efficacy of CD19 CAR T-cell therapy as consolidation treatment in older adults (≥55 years) with B-cell acute lymphoblastic leukemia (B-ALL) in first complete…
Safe Accelerated Venetoclax Escalation: a phase 1b study of obinutuzumab plus venetoclax with daily ramp-up in CLL.
This phase 1b clinical trial evaluated the safety and efficacy of an accelerated 5-day inpatient venetoclax ramp-up in 40 patients with chronic lymphocytic leukemia (CLL).
EuroNet-PHL-LP1: complete resection or low-dose chemotherapy for pediatric low-risk nodular lymphocyte-predominant Hodgkin lymphoma.
The EuroNet-PHL-LP1 trial evaluated treatment strategies for pediatric patients with early-stage nodular lymphocyte-predominant Hodgkin lymphoma (nLPHL).
Long-term outcomes of azacitidine, venetoclax, and gilteritinib in newly diagnosed FLT3-mutated AML.
This phase II clinical trial evaluated the long-term outcomes of azacitidine, venetoclax, and gilteritinib in 30 adults with newly diagnosed FLT3-mutated acute myeloid leukemia (AML) unfit for intensive chemotherapy.
Baricitinib for refractory chronic graft-versus-host disease: results of a phase 1/2 study.
This phase 1/2 study evaluated the safety and efficacy of baricitinib, a JAK 1/2 inhibitor, in 24 adults with refractory chronic graft-versus-host disease (cGVHD) after hematopoietic cell transplantation.
Safety and efficacy of allogeneic CD19-directed CAR-T therapy CTX110 in relapsed/refractory B-cell non-Hodgkin lymphoma.
This multicenter, single-arm, phase 1/2 trial assessed the safety and efficacy of CD19-directed CAR-T therapy CTX110 in 63 adults with relapsed/refractory B-cell non-Hodgkin lymphoma.
Instruments for measuring body image in breast cancer patients: a systematic review of measurement properties.
This systematic review evaluated the psychometric properties of patient-reported outcome measures (PROMs) for body image in breast cancer patients. Thirty-eight articles assessing fifteen PROMs were included.
Induction and consolidation atezolizumab with stereotactic body radiation therapy versus radiation alone in high-risk, early-stage non-small-cell lung cancer (SWOG/NRG S1914): a multicentre, open-label, superiority, phase 3, randomised controlled trial.
This phase 3, multicentre, randomised controlled trial evaluated the addition of atezolizumab to stereotactic body radiation therapy (SBRT) in patients with high-risk, early-stage non-small-cell lung cancer (NSCLC).
DSM-TACE Versus Conventional Approaches in HCC: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared degradable starch microsphere transarterial chemoembolization (DSM-TACE) with conventional TACE or drug-eluting bead TACE in patients with hepatocellular carcinoma.
Indwelling pleural catheter enabling safe air travel in malignant pleural effusion with pneumothorax ex vacuo.
A man with pleural mesothelioma developed a large left hydropneumothorax after drainage of malignant pleural effusion. An indwelling pleural catheter was placed, allowing for management of symptoms and the risk of air…
Single-fraction stereotactic radiosurgery vs. hypofractionated stereotactic radiotherapy for resected brain metastases: a systematic review and meta-analysis of comparative studies.
This systematic review and meta-analysis evaluated the effectiveness of single-fraction stereotactic radiosurgery (SF-SRS) versus hypofractionated stereotactic radiotherapy (HF-SRT) in adults with resected brain…
Cardiac metastases from colorectal cancer: a comprehensive systematic review of clinical presentation, cardiac involvement, and outcomes.
Cardiac metastasis from colorectal cancer (CRC) is exceedingly rare and remains poorly defined in the literature. As survival improves and metastatic patterns evolve, recognizing the clinical and anatomical…
The effect of a smartphone-based educational intervention on the supportive care needs of family caregivers of patients with colorectal cancer: a randomized controlled trial.
This randomized controlled trial evaluated the impact of a smartphone-based educational program on the supportive care needs of family caregivers of colorectal cancer patients.
First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations.
This Phase I, open-label, multicenter trial evaluated the safety and preliminary efficacy of the PARP inhibitor HWH340 in patients with advanced solid tumors, particularly those with homologous recombination repair gene…
Gastric perforation repaired by hepatic round ligament: Case report and literature review.
A 44-year-old male with advanced gastric adenocarcinoma and peritoneal carcinomatosis presented with acute abdomen after stent insertion. Imaging confirmed gastric perforation and generalized peritonitis.
Heparin-free veno-venous extracorporeal membrane oxygenation as a bridge therapy for airway interventions in malignant central airway obstruction: Case series and literature review.
Three patients with malignant central airway obstruction (MCAO) presented with severe respiratory failure due to bronchial obstruction from tumors.
A systematic review and network meta-analysis of single nucleotide polymorphisms associated with oral submucous fibrosis risk.
This systematic review and network meta-analysis evaluated the association between single nucleotide polymorphisms (SNPs) and the risk of oral submucous fibrosis (OSF) in a population of 2545 cases and 3772 controls.
High-grade B-cell lymphoma presenting with bulbar palsy and Tapia syndrome: A case report.
A 46-year-old male presented with dysphagia, which led to the diagnosis of high-grade B-cell lymphoma. His symptoms included bulbar palsy and Tapia syndrome, which are uncommon initial manifestations of lymphoma.
A rare case of metastatic Merkel cell carcinoma presenting without a primary cutaneous lesion: A case report.
A 44-year-old male presented with a painless, enlarging mass in the right groin, with no prior skin lesions. Pathological examination confirmed metastatic Merkel cell carcinoma (MCC) through immunohistochemical…
Evaluating the potential of candidate surrogate endpoints for overall survival in treatment-naive metastatic melanoma treated with anti-PD-1-based regimens with or without anti-CTLA-4 therapy.
This meta-analysis evaluated potential surrogate endpoints for overall survival (OS) in 1865 treatment-naive metastatic melanoma patients receiving anti-PD-1 regimens.
Synthetic long peptide and DNA personalized cancer vaccines induce robust neoantigen-specific T cell responses in pancreatic cancer.
This phase I clinical trial evaluated the safety and immunogenicity of synthetic long peptide and DNA personalized cancer vaccines in patients with resected pancreatic ductal adenocarcinoma.
Artificial Intelligence for Diagnosis, Risk Stratification, and Prognosis of Neuroblastoma - A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the performance of artificial intelligence (AI) in diagnosing, risk stratifying, and prognosing neuroblastoma across 53 studies.
Clinical Relevance of Post-Treatment Circulating Tumor DNA Detection in Early Breast Cancer Using a Tissue-Free Epigenomic Assay: A 2-Year Landmark Analysis.
This phase III clinical trial evaluated the prognostic value of post-treatment circulating tumor DNA (ctDNA) detection in 313 patients with early-stage breast cancer.
Neoadjuvant combined immunotherapy with intratumoral TransCon TLR7/8 Agonist and systemic TransCon IL-2 β/y or pembrolizumab in patients with locally advanced oral cancer-a monocentric experience.
Combination immunotherapy has shown encouraging activity across multiple solid tumors. We report the complete and consecutive cohort of patients with locally advanced oral squamous cell carcinoma (OSCC) treated at a…
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