Trending archive
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1891 articles
March 202624
Suppressed gonadotropins as a warning sign of an extragonadal tumor in an adolescent with Klinefelter syndrome.
An adolescent with Klinefelter syndrome was found to have a mediastinal germ cell tumor. The diagnostic clue was an unusual gonadotropin profile, with suppressed gonadotropins prompting recognition of the extragonadal…
Global HPV genotype distribution and coinfections in oropharyngeal squamous cell carcinoma: systematic review and meta-analysis.
This systematic review and meta-analysis examined global HPV prevalence, genotype distribution, and coinfections in biopsy-confirmed oropharyngeal squamous cell carcinoma (OPSCC).
Cervical Small Cell Neuroendocrine Carcinoma Initially Detected on Cytology: Diagnostic Pitfalls and Clues.
A patient’s cervical small cell neuroendocrine carcinoma was first detected on conventional endometrial and cervicovaginal liquid-based cytology.
Can pelvic lymph node dissection be spared in intermediate-risk prostate cancer patients with negative PSMA PET scan? A systematic review and diagnostic meta-analysis.
This systematic review and diagnostic meta-analysis assessed PSMA PET/CT for detecting lymph node invasion in intermediate-risk prostate cancer and considered whether a negative scan could support omitting pelvic lymph…
Beyond rejection risk: Identifying ideal candidates for pretransplant immune checkpoint inhibitors for HCC.
This systematic review assessed immune checkpoint inhibitors (ICIs) used as bridging or downstaging therapy before liver transplantation for hepatocellular carcinoma.
Advances and Challenges in the Multidisciplinary Treatment of Retroperitoneal Infantile Fibrosarcoma in Early Life.
This retrospective case series describes three infants with histologically confirmed retroperitoneal infantile fibrosarcoma, diagnosed at a median age of 2 months (range: 0-8 months).
Efficacy of concurrent hyperbaric oxygen therapy with chemoradiotherapy for glioma: a meta-analysis.
This systematic review and meta-analysis assessed concurrent hyperbaric oxygen therapy (HBOT) with chemoradiotherapy in patients with glioma. It included nine randomized controlled trials involving 837 patients.
Complete Mesocolic Excision Versus D2 Lymphadenectomy for Right Colon Cancer: A Bayesian Meta-Analysis of Randomized Trials Assessing Surgical and Perioperative Outcomes.
This systematic review and Bayesian meta-analysis compared complete mesocolic excision (CME) with D2 lymphadenectomy for right colectomy in patients with right-sided colon cancer.
Lung Cancer Initially Presenting with Diffuse Alveolar Damage and Brain Infarction: An Autopsy Case Report.
A 67-year-old man presented with dyspnea, right hemiparesis, and dysarthria. Chest CT showed extensive pulmonary infiltrates and a small left upper-lobe nodule; brain MRI demonstrated multiple acute cerebral infarctions.
Pulmonary Cryptococcosis Mimicking Lung Metastasis in a Patient with Pancreatic Cancer: A Case Report and Review of the Literature.
A man with pancreatic head cancer, liver metastases, and a germline BRCA2 mutation received FOLFOX chemotherapy. Although the primary tumor responded and CA19-9 levels declined, imaging showed a rapidly enlarging…
Favorable Response to Chemotherapy with Durvalumab Plus Tremelimumab in Two Cases of KRAS G12C-positive Pulmonary Sarcomatoid Carcinoma.
Two men, aged 69 and 66 years, had metastatic pulmonary sarcomatoid carcinoma with KRAS G12C mutations. Both received chemotherapy combined with durvalumab and tremelimumab using the POSEIDON regimen.
Combined Hepatocellular-cholangiocarcinoma Patient Treated with Durvalumab Plus Gemcitabine and Cisplatin.
A 55-year-old man with lower abdominal pain and diarrhea was referred to our hospital. Computed tomography (CT) revealed a hypovascular liver tumor, lymph node/bone metastases, and peritoneal dissemination.
Tumor Purity as a Prognostic and Predictive Biomarker of Postoperative Radiation Therapy Outcomes in Stage IIIA-N2 Non-Small Cell Lung Cancer: A Transcriptomic Analysis From the Lung ART Trial.
This transcriptomic analysis of the randomised Lung ART-IFCT 0503 trial examined tumor purity (TP) as a prognostic and potential predictive biomarker in 285 patients with resected stage IIIA-N2 non-small cell lung…
Long-Term Analysis of One Versus Three Fractions of Stereotactic Body Radiation Therapy for Peripheral Stage I to II Non-Small Cell Lung Cancer: A Randomized, Multi-Institution, Phase 2 Trial.
This multicentre, randomised phase 2 trial compared long-term outcomes after stereotactic body radiotherapy delivered as 30 Gy in 1 fraction or 60 Gy in 3 fractions.
Constraints, Cumulative Doses, and Toxicity Outcomes in Glioma Reirradiation: A Systematic Review and Radiobiological Comparison From the Reirradiation Collaborative Group (ReCOG).
This systematic review examined organ-at-risk constraints, planned cumulative doses and toxicity outcomes in adults receiving reirradiation for recurrent glioma. It included 27 studies, most involving glioblastoma.
Effect of Narrative-Based Palliative Care on Psychological Stress, Quality of Life, and End-of-Life Acceptance in Elderly Terminal Cancer Patients and Their Families.
This single-center randomized controlled study evaluated narrative-based palliative care in 50 elderly patients with terminal cancer and their family caregivers.
Risk of adverse events in elotuzumab-treated patients with multiple myeloma: a systematic review and meta-analysis.
This systematic review and meta-analysis pooled adverse-event data from six randomized controlled trials involving 1,736 patients with multiple myeloma treated with elotuzumab-containing regimens or control therapies.
Prophylactic Recombinant Human Thrombopoietin Prevents Cancer Therapy-Induced Thrombocytopenia During Concurrent Chemoradiation Therapy in Limited-Stage Small Cell Lung Cancer: A Prospective, Multicenter, Phase II Clinical Trial.
This prospective, multicenter, phase II trial assessed prophylactic recombinant human thrombopoietin (rhTPO) during concurrent chemoradiation in patients with limited-stage small cell lung cancer.
Stated Preferences for Systemic Treatments for Prostate Cancer: A Targeted Review of the Discrete-Choice Experiment Literature.
This targeted review summarized discrete-choice experiment studies of patient and healthcare professional preferences for systemic prostate cancer treatments.
Changes in quality of life in colorectal cancer screening: A multicentre trial in populations in China.
This multicentre randomised trial assessed quality of life among 19,373 participants in China allocated to one-time colonoscopy, annual faecal immunochemical testing (FIT) with colonoscopy after a positive result, or…
Quality of Life in Patients With p16+ Oropharyngeal Cancer Receiving Accelerated Radiation Therapy With Either Cisplatin or Cetuximab in the NRG/RTOG 1016 Randomized Controlled Trial.
This phase III randomized controlled trial examined quality of life (QOL) in patients with p16-positive oropharyngeal cancer receiving accelerated intensity-modulated radiation therapy (70 Gy/6 weeks) with either…
Relationship between menopausal hormone therapy and incidence risk of breast cancer: systematic review and meta-analysis.
This systematic review and meta-analysis assessed the association between menopausal hormone therapy (MHT) and breast cancer incidence across 34 studies.
Upfront 177 Lu-PSMA Radioligand Therapy With Concurrent Androgen-deprivation Therapy Producing Dramatic Clinical and Biochemical Response : A Case Report.
A 72-year-old man presented with severe weight loss, anemia, and a PSA of 73 ng/mL. Bone scintigraphy and 99m Tc-PSMA imaging showed extensive skeletal metastases.
Severe Aplastic Anemia Concurrent with Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia.
A 79-year-old woman presented with progressive dyspnea. Bone marrow biopsy showed hypoplastic marrow containing abnormal lymphoid cells, and genetic analysis identified a MYD88 p.V204F mutation supporting…
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