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281 articles

October 202624

Clinical ResearchPediatricsOpen access

Immediate vs delayed extubation after pediatric liver transplantation: a systematic review and meta-analysis.

This systematic review and meta-analysis compared immediate operating-room extubation with delayed extubation after pediatric orthotopic liver transplantation.

Eur J PediatrOct 23, 2026Read summary
Clinical ResearchObstetrics & GynecologyOpen access

Combined transcutaneous electrical nerve stimulation and low-level laser photobiomodulation for postoperative pain after cesarean section: A randomized controlled trial.

This randomized controlled trial compared combined transcutaneous electrical nerve stimulation (TENS) and low-level laser photobiomodulation (PBM) with TENS alone, placebo, and control for postoperative recovery after…

PLoS OneOct 22, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Bolus-only versus bolus plus continuous infusion hydromorphone for refractory cancer pain: a prospective, multicenter, randomized noninferiority trial.

This prospective, multicenter, randomized noninferiority trial compared bolus-only patient-controlled intravenous hydromorphone analgesia with bolus plus continuous infusion in patients with refractory cancer pain.

Support Care CancerOct 22, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Clinical safety, tolerability, and efficacy of fospropofol disodium for sedation: a systematic review.

This systematic review and meta-analysis assessed randomized trials of fospropofol for procedural and ICU sedation. It included 10 studies: six procedural-sedation trials and four ICU-sedation trials.

Eur J Clin PharmacolOct 22, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Tranexamic acid in laparoscopic sleeve gastrectomy: bleeding control amid thrombotic concerns and hemodynamic instability: a randomized double-blinded clinical trial.

This randomized, double-blinded clinical trial assessed tranexamic acid (TXA) for perioperative bleeding prevention in 185 patients with morbid obesity undergoing elective laparoscopic sleeve gastrectomy.

Acta Cir BrasOct 19, 2026Read summary
Clinical ResearchAnesthesiology

The Impact of Anaesthesia Method on the Use of Anaesthesia Department Resources in Total Knee Arthroplasty.

This randomised controlled trial compared spinal anaesthesia with general anaesthesia using total intravenous anaesthesia in 395 patients undergoing total knee arthroplasty.

Acta Anaesthesiol ScandOct 18, 2026Read summary
Clinical ResearchAnesthesiology

Nociception Level-Guided Multimodal Analgesia with External Oblique Intercostal Plane Block in Laparoscopic Cholecystectomy.

This double-blind randomized controlled trial compared nociception level (NOL)-guided multimodal analgesia (MMA) incorporating an external oblique intercostal plane (EOIP) block with intravenous dexketoprofen alone in…

J Vis ExpOct 16, 2026Read summary
Clinical ResearchAnesthesiology

Quality of recovery after arthroscopic meniscectomy with remimazolam or propofol anesthesia: A randomized controlled trial.

This randomized controlled trial compared propofol-based with remimazolam-based total intravenous anesthesia in adults undergoing elective arthroscopic meniscectomy.

PLoS OneOct 15, 2026Read summary
Clinical ResearchAnesthesiology

Pericapsular Nerve Group Block Versus Femoral Nerve Block for Analgesia in Newly Admitted Patients With Hip Fractures: A Randomized Controlled Trial.

This randomized controlled trial compared preoperative pericapsular nerve group (PENG) block with femoral nerve block (FNB) in 60 newly admitted patients with hip fractures.

Clin J PainOct 14, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Perineural versus intravenous dexmedetomidine as an adjuvant for ilioinguinal/iliohypogastric nerve block in open inguinal hernia repair: a randomised controlled trial.

This single-centre, triple-blind randomised controlled trial compared perineural, intravenous and placebo dexmedetomidine as adjuncts to an ilioinguinal/iliohypogastric nerve block in 90 adults undergoing elective open…

HerniaOct 14, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Effect of a Subanesthetic Dose of Esketamine on Postoperative Sleep Disturbance After Oocyte Retrieval Under Intravenous Anesthesia: A Randomized Controlled Trial.

This randomized, double-blind, placebo-controlled trial assessed whether intravenous esketamine reduces postoperative sleep disturbance (PSD) in women undergoing oocyte retrieval with intravenous anesthesia.

Drug Des Devel TherOct 14, 2026Read summary
Clinical ResearchUrologyOpen access

Opioid-free versus opioid-based anesthesia for robot-assisted radical prostatectomy: a single-center randomized controlled trial.

This single-center randomized controlled trial compared opioid-free anesthesia (dexmedetomidine plus ketamine) with remifentanil-based anesthesia in adult men undergoing robot-assisted radical prostatectomy.

J Robot SurgOct 13, 2026Read summary
Clinical ResearchPediatrics

Impact of a Dynamic Visualized Pain Assessment Tool on Pediatric Pain Management: A Stepped-Wedge Cluster Randomized Trial.

This stepped-wedge cluster randomized trial evaluated a dynamic visualized pain assessment tool across five clinical wards, involving 15 infants and 45 video segments spanning baseline, procedural pain, and…

J Vis ExpOct 13, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Analgesic efficacy of uni-level erector spinae plane block in breast cancer surgery patients: a systematic review and Meta-analysis.

This systematic review and meta-analysis assessed uni-level erector spinae plane block (ESPB) as an adjunct to general anesthesia and opioids for breast cancer surgery.

BMC AnesthesiolOct 12, 2026Read summary
Clinical ResearchUrologyOpen access

Bridging evidence gaps in opioid-sparing postoperative pain control for percutaneous nephrolithotomy: a network meta-analysis identifying optimal strategies.

This systematic review and Bayesian network meta-analysis compared postoperative analgesic strategies in adults undergoing percutaneous nephrolithotomy (PCNL), using randomised controlled trials that assessed pain.

UrolithiasisOct 10, 2026Read summary
Clinical ResearchUrology

Lung ultrasound-guided protocolized fluid management versus conventional central venous pressure-based management in monitoring extravascular lung water during the perioperative period of percutaneous nephrolithotomy: a randomized controlled trial.

This randomized controlled trial compared lung ultrasound (LUS)-guided protocolized fluid management with conventional central venous pressure (CVP)-based management in 181 patients undergoing elective percutaneous…

Ann MedOct 9, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Ketamine and esketamine during breastfeeding: a systematic review of human pharmacokinetic, infant and lactation outcomes.

This systematic review synthesised human evidence on ketamine and esketamine transfer into breast milk, infant exposure and outcomes, and breastfeeding outcomes after postpartum exposure.

Eur J Clin PharmacolOct 9, 2026Read summary
Clinical ResearchOrthopedic SurgeryOpen access

Efficacy and safety of intraoperative red blood cell salvage transfusion for spinal deformity surgery: a systematic review and meta-analysis.

This systematic review and meta-analysis pooled 22 observational studies of spinal deformity surgery, including 2,977 patients treated with intraoperative cell salvage (ICS) or without it.

Neurosurg RevOct 9, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Effects of Sodium Bicarbonate Ringer's Solution versus Lactate Ringer's Solution on Emergence Time in Patients Undergoing Supratentorial Tumor Resection: A Randomized Controlled Trial.

This randomized controlled trial compared intraoperative sodium bicarbonate Ringer’s solution (BRS) with lactated Ringer’s solution (LRS) in patients undergoing elective supratentorial tumor resection.

Drug Des Devel TherOct 9, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Effect of Anterior Quadratus Lumborum Block at the Lateral Supra-Arcuate Ligament Combined with Esketamine on the Quality of Postoperative Recovery After Laparoscopic Radical Surgery for Elderly Patients with Colorectal Cancer: A Randomized Controlled Trial.

This single-centre, randomized, placebo-controlled trial evaluated anterior quadratus lumborum block at the lateral supra-arcuate ligament (QLB-LSAL), low-dose esketamine, or their combination in patients aged 60 years…

Drug Des Devel TherOct 8, 2026Read summary
Clinical ResearchAnesthesiology

Effects of remimazolam versus propofol on cerebral oxygenation in elderly patients undergoing prone spine surgery: study protocol for a randomised controlled trial.

This article describes the protocol for a prospective, single-centre randomised controlled trial comparing remimazolam with propofol-based total intravenous anaesthesia in elderly patients undergoing elective thoracic…

BMJ OpenOct 7, 2026Read summary
Clinical ResearchAnesthesiology

Daily sedation interruption versus no daily sedation interruption for critically ill adults and children requiring invasive mechanical ventilation.

This updated Cochrane systematic review and meta-analysis assessed daily sedation interruption (DSI) versus sedation strategies without interruption in critically ill adults and children receiving invasive mechanical…

Cochrane Database Syst RevOct 7, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Survival outcomes following total intravenous versus volatile anesthesia in esophagogastric cancer surgery: a systematic review and meta-analysis.

This systematic review and meta-analysis compared total intravenous anesthesia (TIVA) with volatile anesthesia in adults undergoing curative surgery for esophageal or gastric cancer.

Langenbecks Arch SurgOct 7, 2026Read summary
Clinical ResearchPulmonology

Digital Twin-Assisted Risk Disclosure in Adults Undergoing Elective Bronchoscopy: Multicenter Randomized Controlled Trial.

This multicenter randomized controlled trial evaluated the impact of digital twin-assisted risk disclosure on prebronchoscopy anxiety and postbronchoscopy satisfaction in adults undergoing elective bronchoscopy.

J Med Internet ResOct 6, 2026Read summary

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