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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedClinical ResearchPsychiatry

Efficacy and safety of GLP-1 receptor agonists for antipsychotic-related overweight and metabolic dysregulation: a systematic review and meta-analysis.

Eur J Clin PharmacolOct 24, 2026Open access

This systematic review and meta-analysis pooled randomized controlled trials of GLP-1 receptor agonists in adults receiving antipsychotic treatment for overweight or metabolic dysregulation.

Why it matters

Antipsychotic-associated weight and metabolic changes can be clinically important, and these pooled trial results suggest GLP-1RAs may improve weight-related and glycemic measures in this population.

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Also worth knowing

Clinical ResearchObstetrics & Gynecology

The Impact of Telemedicine Interventions on Maternal and Fetal Outcomes in Women With Gestational Diabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

This systematic review and meta-analysis pooled 23 randomized controlled trials involving 3055 women with gestational diabetes to assess telemedicine and maternal and fetal outcomes.

J Med Internet ResOct 23, 2026Read summary
Clinical ResearchEndocrinology

Evaluating Improvement in Pain and Sensory Function When Using High-Frequency (10-kHz) Spinal Cord Stimulation in Individuals With Painful Diabetic Neuropathy: A Multicenter Randomized Controlled Trial (PDN-Sensory).

The multicenter randomized controlled PDN-Sensory trial evaluated 10-kHz spinal cord stimulation (SCS) plus conventional medical management (CMM) versus CMM alone in people with painful diabetic neuropathy.

Diabetes CareOct 21, 2026Read summary
Clinical ResearchMedical Genetics

The extra X chromosome and autoimmune susceptibility in Klinefelter syndrome.

This systematic review and meta-analysis assessed autoimmune susceptibility in people with Klinefelter syndrome (47,XXY), using studies of autoimmune disease and serological markers.

J Clin Endocrinol MetabOct 16, 2026Read summary
Clinical ResearchCardiology

Efficacy and safety of baxdrostat in the management of uncontrolled hypertension: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed baxdrostat versus placebo in randomized controlled trials involving patients with uncontrolled hypertension.

Am J HypertensOct 15, 2026Read summary
Clinical ResearchCardiology

Efficacy and Safety of Enlicitide in Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

This systematic review and random-effects meta-analysis assessed efficacy and safety of oral enlicitide in adults with hypercholesterolemia.

Endocrinol Diabetes MetabOct 14, 2026Read summary
Clinical ResearchEndocrinology

Search for the glycated hemoglobin target minimizing mortality among people with type 2 diabetes with rare incidence of treatment-related severe hypoglycemia - Epidemiologic analysis of J-DOIT3 randomized controlled trial.

This landmark analysis of the J-DOIT3 randomized controlled trial examined associations between updated HbA1c and cardiovascular outcomes or mortality among people with type 2 diabetes, in a setting where severe…

PLoS OneOct 23, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Maternal and Neonatal Complications in Pregnant Women With Polyendocrine Metabolic Ovarian Syndrome: A Nested Prospective Cohort Study.

This prospective nested cohort study examined associations between polyendocrine metabolic ovarian syndrome (PMOS) and pregnancy outcomes among 3,645 pregnant women with risk factors for hyperglycemia enrolled in an…

Diabetes CareOct 22, 2026Read summary
Clinical ResearchPsychiatry

Semaglutide modulates explore/exploit decision-making in major depressive disorder: A randomized clinical trial.

This secondary analysis of a randomized clinical trial examined whether semaglutide affected explore/exploit decision-making in 72 participants with major depressive disorder (MDD).

Psychol MedOct 21, 2026Read summary
Clinical ResearchGastroenterology

Gut virome remodeling after fecal microbiota transplantation is associated with virus-bacteria co-variation and metabolic response in obesity and type 2 diabetes.

This randomized controlled trial examined longitudinal fecal virome and bacteriome changes after fecal microbiota transplantation (FMT) in people with obesity and type 2 diabetes.

Gut MicrobesOct 23, 2026Read summary
Clinical ResearchEndocrinologyOpen access

Skeletal effects of GLP-1 receptor agonist therapy in adults with overweight or obesity: a systematic review.

This systematic review examined randomized evidence on bone mineral density (BMD) and bone-turnover markers in adults with overweight or obesity receiving GLP-1 receptor agonists.

Arch OsteoporosOct 23, 2026Read summary
Clinical ResearchEndocrinology

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes.

This analysis examined whether baseline serum metabolites could predict response to teplizumab in 41 people newly diagnosed with type 1 diabetes who participated in the randomized AbATE trial.

DiabetesOct 21, 2026Read summary

Showing 12 of 27 publications that cleared our clinical screen in the last 14 days.

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