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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedClinical ResearchGastroenterology

Acetic acid chromoendoscopy for detection of neoplastic Barrett's oesophagus: stepped wedge cluster randomised controlled trial (ACID-trial).

BMJOct 21, 2026

This prospective, open-label, stepped-wedge cluster randomised trial assessed whether acetic acid chromoendoscopy (AAC) improved detection of dysplasia or oesophageal adenocarcinoma during Barrett’s oesophagus…

Why it matters

The trial evaluates an added endoscopic technique in routine Barrett’s surveillance and distinguishes increased visual suspicion from improved detection of confirmed neoplasia.

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Also worth knowing

Clinical ResearchGastroenterology

Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis.

This phase 2b, double-blind, randomized trial evaluated once-daily oral icotrokinra, an interleukin-23 receptor blocker, in adults with moderately to severely active ulcerative colitis.

N Engl J MedOct 15, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Clinical safety, tolerability, and efficacy of fospropofol disodium for sedation: a systematic review.

This systematic review and meta-analysis assessed randomized trials of fospropofol for procedural and ICU sedation. It included 10 studies: six procedural-sedation trials and four ICU-sedation trials.

Eur J Clin PharmacolOct 22, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Neoadjuvant Therapy for Gastric Adenocarcinoma with Signet Ring Cells: A Systematic Review and Meta-Analysis.

This systematic review and random-effects meta-analysis assessed neoadjuvant chemotherapy followed by surgery versus upfront gastrectomy in adults with signet ring cell-containing gastric cancer.

J Gastrointest CancerOct 20, 2026Read summary
Clinical ResearchGastroenterology

Safety, Tolerability and Antiviral Activity of GST-HG131 in Chronic Hepatitis B: A Randomized, Double-Blind Phase IIa Study.

This randomized, double-blind, placebo-controlled Phase IIa trial assessed oral GST-HG131 in 45 adults with chronic hepatitis B receiving nucleos(t)ide analogue monotherapy.

Liver IntOct 14, 2026Read summary
Clinical ResearchOncology (Medical)

Impact of body composition on clinical outcomes in patients with hepatocellular carcinoma: A systematic review and meta-analysis.

This systematic review and meta-analysis examined associations between body composition and outcomes in patients with hepatocellular carcinoma (HCC), across curative, locoregional, systemic, and mixed treatment…

Hepatol CommunOct 14, 2026Read summary
Clinical ResearchGastroenterologyOpen access

Switching from Intravenous to Subcutaneous Infliximab in Children with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis synthesized six independent, largely observational cohorts of children with inflammatory bowel disease who switched from intravenous to subcutaneous infliximab (n = 173).

Curr Gastroenterol RepOct 17, 2026Read summary
Clinical ResearchGastroenterology

Global Underutilization of Antiviral Therapy and Survival Outcomes in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of 78 Studies and 68,243 Patients.

This systematic review and meta-analysis assessed antiviral use and its association with survival and hepatocellular carcinoma (HCC) recurrence in adults with HBV-related HCC.

J Viral HepatOct 15, 2026Read summary
Clinical ResearchGastroenterology

Impact of YAQ001 on the Gut Microbiome, Permeability and Markers of Systemic Inflammation in Patients With Cirrhosis.

This double-blind randomised controlled substudy examined YAQ001’s effects on the gut microbiome and exploratory markers of gut permeability and systemic inflammation in 28 patients with cirrhosis.

Liver IntOct 23, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Association between cancer cachexia and treatment-related adverse outcomes in patients with gastrointestinal cancers: a systematic review and meta-analysis.

This systematic review and meta-analysis examined cohort studies of cancer cachexia and treatment-related outcomes in patients with gastrointestinal cancers.

Support Care CancerOct 23, 2026Read summary
Clinical ResearchGastroenterologyOpen access

Patients with MASH experience worse health-related quality of life: a multinational real-world study using LiverMultiScan.

This multinational real-world randomised controlled trial examined health-related quality of life (HRQoL) and liver MRI markers in 802 people with suspected MASLD/MASH across four European countries.

Qual Life ResOct 22, 2026Read summary
Clinical ResearchPediatricsOpen access

Immediate vs delayed extubation after pediatric liver transplantation: a systematic review and meta-analysis.

This systematic review and meta-analysis compared immediate operating-room extubation with delayed extubation after pediatric orthotopic liver transplantation.

Eur J PediatrOct 23, 2026Read summary

Showing 12 of 29 publications that cleared our clinical screen in the last 14 days.

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