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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedClinical ResearchNeurology

Real-world safety and efficacy of lecanemab in the treatment of Alzheimer's disease: a systematic review and meta-analysis.

J NeurolOct 21, 2026Open access

This systematic review and meta-analysis pooled real-world studies of lecanemab treatment in people with Alzheimer’s disease, including 37 studies.

Why it matters

Real-world pooled estimates provide context for lecanemab safety beyond controlled trials, including variation in ARIA rates by APOE ε4 status and baseline microhemorrhage.

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Also worth knowing

Clinical ResearchGeriatrics

Feasibility of a Co-Designed Personalized Cognitive Reablement Program Delivered via Digital Voice Assistants for Older Adults Living With Early-Stage Dementia or Mild Cognitive Impairment: Pilot Randomized Controlled Trial.

This nonblinded pilot randomized controlled trial assessed the feasibility and potential effectiveness of VOICE-COG, a personalized cognitive reablement program delivered through digital voice assistants, in adults aged…

JMIR AgingOct 23, 2026Read summary
Clinical ResearchGeriatrics

Agreement Between In-Person and Telephone Application of the Informant Questionnaire on Cognitive Decline in the Elderly.

This methodological study assessed agreement between in-person and telephone administration of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), completed by caregivers or family members of older…

PsychogeriatricsOct 22, 2026Read summary
Clinical ResearchGeriatricsOpen access

Feasibility of a multidimensional interdisciplinary rehabilitation program for people with dementia and their informal primary caregivers - a randomized pilot trial with a caregiver focus.

This randomized pilot trial assessed the feasibility of a person-centred, interdisciplinary rehabilitation program for community-dwelling people with dementia that also provided education and support to informal…

BMC GeriatrOct 21, 2026Read summary
Clinical ResearchGeriatricsOpen access

Optimizing exercise prescriptions for older adults with mild cognitive impairment: a dose-response network meta-analysis of modality-dose combinations on executive function.

This Bayesian dose-response network meta-analysis synthesized randomized controlled trials of repeated exercise programmes in adults aged 60 years or older with mild cognitive impairment.

PeerJOct 20, 2026Read summary
Clinical ResearchRheumatologyOpen access

The Effect of Mindfulness-Based Cognitive Therapy on Kinesiophobia in Older Adults with Chronic Knee Osteoarthritis: A Randomized Controlled Trial.

This randomized controlled trial evaluated mindfulness-based cognitive therapy (MBCT) for kinesiophobia in 56 older adults with chronic knee osteoarthritis in Kashan, Iran.

Clin Interv AgingOct 20, 2026Read summary
Clinical ResearchGeriatrics

A Methodological Framework for a Large Language Model Virtual Companion for Older Adults at Risk of Social Isolation.

This paper presents a methodological framework for developing and evaluating a large language model (LLM)-driven virtual companion for older adults at risk of social isolation.

J Vis ExpOct 23, 2026Read summary
Clinical ResearchGeriatrics

Informal Caregiver-Observed Fall Risk Indicators and Caregiver Responses to Prevent Falls Among Community-Dwelling Older People: A Systematic Review.

This systematic review synthesized 16 studies of informal caregivers’ observations of fall-risk indicators and their preventive responses among community-dwelling older people.

J Nurs ScholarshOct 24, 2026Read summary
Clinical ResearchGeriatricsOpen access

Outdoor cycling competence and balance control in older adults - cross-sectional analysis of the BiPerAge trial.

This exploratory cross-sectional analysis used baseline data from a two-center randomized controlled trial to examine balance and outdoor cycling competence in 116 community-dwelling adults aged ≥ 65 years who made at…

BMC GeriatrOct 19, 2026Read summary
Clinical ResearchRadiology (Diagnostic)

The entorhinal cortex atrophy score for diagnostic distinction between phases of the Alzheimer's disease continuum.

This systematic review assessed the Entorhinal Cortex Atrophy (ERICA) visual score for distinguishing subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s disease (AD) dementia.

Arq NeuropsiquiatrOct 23, 2026Read summary
Clinical ResearchGeriatricsOpen access

Thermographic outcomes of auricular laser acupuncture and auricular seed acupressure in older adults with chronic shoulder pain: an exploratory nonrandomized, nonconcurrent comparison.

This exploratory, open-label, nonrandomized comparison studied 20 adults aged 60–90 years with chronic shoulder pain, allocated by order of entry to auricular laser acupuncture or seed acupressure.

Lasers Med SciOct 21, 2026Read summary
Clinical ResearchGeriatrics

Effectiveness of traditional mind-body exercises on fall risk test scores and balance in older adults: A systematic review and meta-analysis.

This systematic review and meta-analysis pooled 31 randomized controlled trials involving 3,622 older adults to assess traditional mind-body exercises and fall-risk test scores and balance.

Medicine (Baltimore)Oct 16, 2026Read summary

Showing 12 of 19 publications that cleared our clinical screen in the last 14 days.

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