Effectiveness and safety of atorvastatin/ ezetimibe fixed-dose combination in hypercholesterolemia: a systematic review and network meta-analysis.
This systematic review and network meta-analysis compared atorvastatin alone with atorvastatin/ezetimibe free-equivalent and fixed-dose combinations in people with hypercholesterolemia.
Why it matters
For patients with hypercholesterolemia who do not reach LDL-C targets on statin monotherapy, these pooled trial findings indicate that adding ezetimibe can improve LDL-C lowering.