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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedClinical ResearchOncology (Medical)

Osimertinib With or Without Chemotherapy in Advanced Non-Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations: A Randomized Clinical Trial.

JAMASep 8, 2026Open access

This phase 3 randomized clinical trial evaluated the efficacy and safety of osimertinib combined with chemotherapy versus osimertinib alone in 294 patients with advanced non-small cell lung cancer (NSCLC) harboring…

Why it matters

The findings suggest that combining osimertinib with chemotherapy may enhance treatment outcomes for patients with specific genetic mutations in advanced NSCLC, potentially guiding personalized treatment strategies.

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Also worth knowing

Clinical ResearchHematology

Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia.

This phase 2 randomized trial compared azacitidine plus venetoclax to induction chemotherapy in 172 previously untreated adults with acute myeloid leukemia (AML) eligible for induction.

N Engl J MedSep 3, 2026Read summary
Clinical ResearchPsychiatry

The efficacy of modified psychodynamic psychotherapy for patients with schizophrenia-spectrum disorders in Germany: a prospective, single-centre, assessor-blinded, parallel-group, randomised controlled trial.

This randomized controlled trial evaluated the efficacy of Modified Psychodynamic Psychotherapy for Schizophrenia (MPP-S) combined with treatment as usual (TAU) in 130 outpatients with schizophrenia-spectrum disorders…

Lancet PsychiatrySep 10, 2026Read summary
Clinical ResearchGeriatrics

Effect of exercise on bone health in middle aged and older adults: hierarchical network meta-analysis of randomised trials.

This hierarchical network meta-analysis evaluated the impact of various exercise types on bone mineral density (BMD) and fracture risk in adults aged 40 and older.

BMJSep 9, 2026Read summary
Clinical ResearchNephrology

Effect of intradialytic exercise on cardiovascular structural and functional parameters in maintenance haemodialysis: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the effects of intradialytic exercise (IDE) on cardiovascular parameters in patients undergoing maintenance haemodialysis (MHD).

BMJ OpenSep 9, 2026Read summary
Clinical ResearchCardiology

Comparative efficacy of LDL-C-lowering therapies in first-time vs. recurrent myocardial infarction prevention: a meta-analysis of large-scale randomized controlled trials.

This meta-analysis evaluated the efficacy of LDL-C-lowering therapies in preventing first-time versus recurrent myocardial infarction (MI) across 22 randomized controlled trials involving 180,304 participants.

Eur J Prev CardiolSep 4, 2026Read summary
Clinical ResearchUrology

PCa Detection in PI-RADS 4 and 5 Lesions: Comparison of [ 68 Ga]Ga-PSMA-11 PET/CT-Guided Robot-Assisted Biopsy Versus mpMRI Cognitive-Fusion TRUS-Guided Prostate Biopsy.

This randomized controlled trial compared the diagnostic performance of robotic arm-assisted [68Ga]Ga-PSMA-11 PET/CT-guided prostate biopsy (PGPB) with mpMRI-directed cognitive-fusion transrectal ultrasound-guided…

J Nucl MedSep 2, 2026Read summary
Clinical ResearchPediatrics

Gastric Residual Volume Assessment in Critically Ill Children: The GASTRIC-PICU Randomized Clinical Trial.

The GASTRIC-PICU trial evaluated the impact of routine gastric residual volume (GRV) assessment on enteral feeding in critically ill children.

JAMASep 8, 2026Open accessRead summary
Clinical ResearchDermatology

Practical Saudi Guidelines on management of moderate-to-severe psoriasis: 2026 update.

This systematic review developed updated clinical practice guidelines for managing moderate-to-severe psoriasis in Saudi Arabia, addressing both adults and pediatric patients.

J Dermatolog TreatSep 7, 2026Read summary
Clinical ResearchEndocrinology

Diabetes-specific nutritional formulas for tube feeding in patients with hyperglycemia: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the effects of diabetes-specific nutritional formulas (DSNF) in tube feeding on glycemic control in patients with hyperglycemia.

BMJ Open Diabetes Res CareSep 9, 2026Read summary
Clinical ResearchPsychiatry

Comparative effectiveness of mood stabiliser monotherapy versus second-generation antipsychotic monotherapy versus combination therapy for continuation and maintenance treatment after a first episode of psychotic mania in North America, Chile, and Spain: a target trial emulation using data from the BD-CAUSAL Collaboration.

This pragmatic clinical trial evaluated the effectiveness of mood stabiliser monotherapy, second-generation antipsychotic monotherapy, and combination therapy in individuals aged 16 and older after a first episode of…

Lancet PsychiatrySep 10, 2026Read summary
Clinical ResearchPlastic Surgery

Liposuction versus conservative therapy for patients with lipoedema in Germany: a multicentre, randomised controlled clinical trial.

This multicentre, randomised controlled trial evaluated the effectiveness of liposuction versus conservative therapy in women with lipoedema and leg pain.

LancetSep 5, 2026Read summary

Showing 12 of 399 publications that cleared our clinical screen in the last 14 days.

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