Primary Nasopharyngeal Melanoma without invasive and Metastasis: A Rare Case Reports and Literature Reviews.

Ear Nose Throat JMar 4, 2024 (epub)
Case ReportOtolaryngology (ENT)Oncology (Medical)Pathology (Anatomic & Clinical)

Jian-Jun Wang, Yao-Dong Huan, Hua Liu

✦ AI-curated · Sources linked

Case in brief

A 59-year-old man presented with persistent nasal congestion and a suspected malignant nasopharyngeal neoplasm. Imaging showed no tissue invasion or lymph-node metastases. The resected lesion was diagnosed as malignant nasopharyngeal melanoma, with immunohistochemistry positive for Melan-A, HMB45, and S100. He underwent complete surgical resection followed by adjuvant radiotherapy. At 2 years of follow-up, there was no recurrence or metastasis, and the reported prognosis was good.

What made this case unusual

Despite the generally poor prognosis described for nasopharyngeal melanoma, this case had no imaging evidence of invasion or nodal metastasis and remained free of recurrence and metastasis at 2 years.

Diagnostic / clinical pearl

In a suspected nasopharyngeal malignancy, immunohistochemical positivity for Melan-A, HMB45, and S100 supported the diagnosis of mucosal melanoma in this case.

Source

PubMed · PMID 38439628

Published in Ear Nose Throat J. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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