A Systematic Literature Review of Interventions to Manage Hiccups in Patients With Cancer Undergoing Active Treatment.

In 30 seconds

This systematic literature review used narrative synthesis to examine interventions for hiccups in patients with cancer receiving active treatment with curative intent. Searches of three databases and hand searching identified 13 eligible articles; most were noninterventional observational studies. The review found promising evidence for steroid rotation, baclofen, and acupuncture. Among pharmacologic approaches, replacing dexamethasone with methylprednisolone or omitting dexamethasone was reported as most beneficial for reducing hiccups; baclofen was also beneficial for chronic or intractable hiccups.

Key findings

• Of 13 included articles, most were noninterventional observational studies.
• Replacing dexamethasone with methylprednisolone or omitting dexamethasone was the most beneficial pharmacologic approach reported.
• Baclofen was reported to reduce chronic or intractable hiccups.
• Acupuncture was identified as an effective nonpharmacologic intervention.

Why it matters

Persistent or intractable hiccups can negatively affect quality of life during cancer treatment. This review brings together limited evidence on potential management approaches, including changes to steroid regimens and nonpharmacologic care. The predominance of observational studies means the findings are promising rather than definitive, underscoring the need for stronger evidence to guide management.

What to keep in mind

The evidence base comprised only 13 articles, most of which were noninterventional observational studies.