Papillary Tumors of the Pineal Region (PTPR) in Pediatric Population: A Case Report and Literature Review.
Beril Balci Topuz, Serra Kamer, Tugce Bozkurt Vardar et al.
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Case in brief
A 3-year-old child was diagnosed with a papillary tumor of the pineal region and underwent subtotal resection. Adjuvant radiotherapy was followed by long-term disease stability: no tumor progression was reported during 9 years and 6 months of follow-up, with stability noted for 9 years and 2 months. The report also reviewed 35 pediatric cases, finding recurrence in 38.8% after gross total resection and 60% after subtotal resection. Spinal dissemination was reported at diagnosis and at recurrence and was associated with poor prognosis.
What made this case unusual
The case describes long-term disease stability after adjuvant radiotherapy following subtotal resection, in a tumor type with substantial recurrence reported in the pediatric case review.
Diagnostic / clinical pearl
Papillary tumors of the pineal region can recur even after gross total resection; the review reports higher recurrence after subtotal resection, supporting careful consideration of adjuvant therapy in selected cases.
Why it matters
The review underscores that pediatric PTPR management remains unsettled and that spinal dissemination, although reported infrequently, was associated with poor prognosis.