IDIOPATHIC RETINITIS VASCULITIS ANEURYSMS AND NEURORETINITIS (IRVAN) TREATED WITH ADALIMUMAB: A CASE REPORT.

Retin Cases Brief RepOct 28, 2026
Case ReportOphthalmology

Lien Van Winckel, Ingele Casteels, Pieter-Paul Schauwvlieghe

✦ AI-curated · Sources linked

Case in brief

An adolescent with idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) was initially treated with panretinal photocoagulation and intravitreal ranibizumab in both eyes. Persistent retinal ischemia and vasculitis prompted subcutaneous adalimumab. At 1.5 years of follow-up, the vasculitis had resolved, some retinal capillary nonperfusion had reversed, and retinal ischemia had substantially regressed.

What made this case unusual

Despite initial laser and anti-VEGF treatment, retinal ischemia and vasculitis persisted; after adalimumab was added, some capillary nonperfusion reversed.

Diagnostic / clinical pearl

In this IRVAN case, persistent vasculitis and ischemia after panretinal photocoagulation and ranibizumab were followed by improvement after adalimumab was added.

Source

PubMed · PMID 40982342

Published in Retin Cases Brief Rep. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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