Autologous Fibrin Glue in Pterygium Surgery as an Alternative to Commercial Fibrin Glue.
Márcia Cristina Todo, André Luiz Sita E Souza Bragante, Ananda Lini Vieira da Rocha et al.
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In 30 seconds
This prospective, randomized, double-blind study compared autologous with commercial fibrin glue for fixing conjunctival-limbal grafts in 42 patients undergoing surgery for primary pterygium. No severe adverse events were reported, and recurrence rates did not differ significantly: 15% with autologous glue versus 5% with commercial glue (P = 0.2918). Subconjunctival hemorrhage was more frequent in the commercial-glue group (P = 0.0355). The authors concluded that autologous fibrin glue had comparable efficacy and safety and could serve as an alternative for graft fixation.
Key findings
- Recurrence was 15% with autologous glue versus 5% with commercial glue (P = 0.2918), with no significant between-group difference.
- Subconjunctival hemorrhage occurred more often with commercial glue (P = 0.0355).
- No severe adverse events were reported; complete graft dehiscence occurred in one patient receiving autologous glue.
Why it matters
Graft fixation is an important component of pterygium surgery, and this randomized comparison suggests that an autologous glue option may achieve outcomes comparable to commercial glue. The findings also identify differences in specific postoperative events, while the recurrence comparison did not establish a significant difference between approaches.
What to keep in mind
The study included 42 patients with primary pterygium, and follow-up assessments ended on postoperative day 180; the findings may not apply to other populations or longer-term outcomes.