Ocular Toxoplasmosis Infection Leading to Uveitis or Chorioretinal Lesions: A Systematic Review.
Kylie Boyd, Kristina Condrey, Ayeisha Rosa Hernandez et al.
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In 30 seconds
This systematic review examined ocular outcomes associated with Toxoplasma gondii infection, including uveitis and chorioretinal lesions. It included 63 articles from 27 countries published between 2000 and 2023, requiring physical examination and laboratory confirmation. Meta-analysis indicated that the proportion of ocular toxoplasmosis cases with lesions was lower than the proportion with uveitis; the highest estimates were reported in Asia. The review also found substantial variation in diagnostic methods and reporting, limiting consistent assessment of disease burden.
Key findings
- The review included 63 articles from 27 countries, spanning publications from 2000 to 2023.
- Reported outcomes included uveitis in 61 articles, chorioretinal lesions in 42, and both in 40.
- Meta-analysis found a lower proportion of ocular toxoplasmosis cases with lesions than with uveitis, with the highest estimates in Asia.
Why it matters
Ocular toxoplasmosis can involve uveitis or chorioretinal lesions, with potentially long-term and irreversible effects. The review highlights that estimates of these outcomes are difficult to compare when diagnostic testing, terminology, and demographic reporting vary. More consistent methods would improve understanding of disease burden across populations.
What to keep in mind
Diagnostic methods and reporting were inconsistent across included articles; uniform diagnostic methodology was found only in studies of congenital cases from monitoring programs.