Hypothalamic-Pituitary Axis Involvement in Primary Central Nervous System Lymphoma.
J Clin Endocrinol MetabSep 16, 2026
Carolina Sager-La Ganga, Víctor Navas-Moreno, Fernando Sebastián-Valles et al.
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In 30 seconds
This systematic review examined endocrine dysfunction related to the hypothalamic-pituitary axis in 99 adult patients with primary central nervous system lymphoma (PCNSL). The study found that 89.7% of patients had gonadal axis involvement and 89.2% had thyroid axis involvement. Hypothalamic tumors were linked to a higher likelihood of combined endocrine dysfunction (odds ratio = 9.47).
Key findings
- Diffuse large B-cell lymphoma comprised 84% of PCNSL cases studied.
- Isolated adenohypophyseal involvement was seen in 46% of patients.
- 89.7% of patients experienced gonadal axis dysfunction.
- Persistent endocrinopathy was more common in patients with progressive disease.
Why it matters
Understanding the prevalence and patterns of endocrine dysfunction in PCNSL is crucial for clinicians, as it can lead to significant complications if unrecognized. Routine screening for hormonal disturbances can improve patient management and outcomes.