Leptomeningeal Metastasis from Colorectal Cancer Treated with Folinic Acid, Fluorouracil, and Oxaliplatin Chemotherapy Plus Bevacizumab: A Case Report.

J Nippon Med SchNov 17, 2025 (epub)
Case ReportOncology (Medical)NeurologyPathology (Anatomic & Clinical)

Tomohiro Hayakawa, Yoshiharu Nakamura, Hiroki Masuda et al.

✦ AI-curated · Sources linked

Case in brief

A 63-year-old man receiving bevacizumab-containing chemotherapy for colorectal cancer was admitted with loss of appetite and frequent episodes of loss of consciousness. Imaging showed no abnormality to explain his symptoms, but cerebrospinal fluid cytology confirmed leptomeningeal metastasis. His symptoms worsened, impairing communication and preventing further chemotherapy. He died 3 weeks after admission.

What made this case unusual

Leptomeningeal metastasis was identified by cerebrospinal fluid cytology despite unrevealing imaging in a patient with colorectal cancer.

Diagnostic / clinical pearl

In a patient with cancer and central nervous system symptoms, normal imaging does not exclude leptomeningeal metastasis; cerebrospinal fluid cytology can establish the diagnosis.

Source

PubMed · PMID 41242722

Published in J Nippon Med Sch. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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