Effects of Gegen-Heisu Decoction on Endometrial Receptivity in Patients with Thin Endometrium-Related Infertility: A Prospective Randomized Controlled Trial.
Xia Lin, Hua Chen, Xiaowei Zhou et al.
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In 30 seconds
This single-center, prospective randomized controlled study evaluated Gegen-Heisu decoction (GHD) added to estradiol and dydrogesterone in 250 women with thin endometrium-related infertility. Compared with hormone therapy alone, the combination significantly improved endometrial thickness (p < 0.001) and endometrial type on the ovulation day (p = 0.005). It was also associated with improved uterine spiral artery blood-flow measures, lower traditional Chinese medicine syndrome scores, and higher serum leukemia inhibitory factor levels. Reported adverse effects were mild; no hepatic or renal adverse effects were observed.
Key findings
- Endometrial thickness improved with GHD plus hormone therapy versus hormone therapy alone (p < 0.001).
- Endometrial type on the ovulation day differed significantly between groups (p = 0.005).
- The GHD group had lower uterine spiral artery pulsation and resistance indices and higher peak systolic velocity (p < 0.05).
- Serum leukemia inhibitory factor was higher (p = 0.003), and syndrome scores were lower (p < 0.001) with GHD.
Why it matters
Endometrial thickness, morphology, and blood flow are relevant measures of endometrial receptivity in thin-endometrium-related infertility. This trial reports improvements in these measures when GHD was added to estrogen-progestin therapy, alongside changes in a serum marker. These findings may inform further evaluation of the adjunct, but the abstract does not report pregnancy or live-birth outcomes.
What to keep in mind
The study was conducted at a single center, and the abstract does not report pregnancy or live-birth outcomes.