Comparative Analysis of Microneedling With PRP Versus Vitamin C Serum in the Management of Post-Operative Cleft lip Scars.
Sameera Dawar, Manu Gupta, Varun Arya et al.
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In 30 seconds
This prospective randomized comparative study assessed microneedling with platelet-rich plasma (PRP) versus vitamin C serum for postoperative cleft lip scars. Thirty participants were allocated to two groups of 15, and each received three microneedling sessions with the assigned adjunct. Scar outcomes were evaluated using the patient and observer scar assessment scale at 1, 2, and 3 months. Both groups improved, while PRP was associated with greater scar reduction and patient-reported satisfaction (p < 0.05). Between-group differences in pliability (p = 0.10) and pain (p = 0.28) were not statistically significant.
Key findings
- Both microneedling adjuncts improved scar appearance, texture, and overall aesthetic outcomes.
- PRP showed greater scar reduction and patient-reported satisfaction than vitamin C serum (p < 0.05).
- Pliability (p = 0.10) and pain (p = 0.28) did not differ significantly between groups.
Why it matters
Postoperative cleft lip scars can affect appearance and patient satisfaction. This small randomized comparison suggests that the choice of adjunct to microneedling may influence some scar outcomes, while not all assessed domains differed. The findings help frame the potential role of PRP relative to vitamin C serum, but require cautious interpretation given the limited study population.
What to keep in mind
The study included only 30 participants, with 15 per group, and follow-up evaluations extended to 3 months.