Bilateral hypertensive retinopathy (grade 4): Case report and review of the literature on intravitreal injection anti-VEGF therapy.

Clin Exp HypertensDec 23, 2025 (epub)
Case ReportOphthalmology

Yang Jianjun

✦ AI-curated · Sources linked

Case in brief

Three patients with bilateral grade 4 hypertensive retinopathy and macular edema were assessed by fundus examination and treated with intravitreal anti-VEGF injections. After treatment, macular edema and optic nerve edema were reduced, and visual acuity improved. The report also identified secondary choroidal neovascularization in a patient with grade 4 hypertensive retinopathy. The authors described the treatment response as satisfactory but incomplete; the abstract does not provide further patient-level diagnostic or outcome details.

What made this case unusual

The report notes secondary choroidal neovascularization in the setting of grade 4 hypertensive retinopathy, alongside bilateral macular and optic nerve edema.

Diagnostic / clinical pearl

In severe hypertensive retinopathy, assess for macular edema, optic nerve edema, and secondary choroidal neovascularization; the reported patients showed improvement in edema and visual acuity after intravitreal anti-VEGF treatment.

Source

Published in Clin Exp Hypertens. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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