Predictive Value of Lymphocyte-Based Inflammation Index for Clinical Outcome in Patients With Lower Extremity Arteriosclerosis Obliterans: A Systematic Review and Meta-Analysis.
ZeSen Huang, XuHao Ni, QuanFu Dai
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis assessed whether lymphocyte-based inflammatory indices predict outcomes in patients with lower extremity arteriosclerosis obliterans. It included 33 studies with 12 386 participants and examined mortality, amputation, restenosis, major adverse limb events, and amputation-free survival. High neutrophil-to-lymphocyte ratio (NLR) was associated with mortality (OR: 1.31; 95% CI: 1.17-1.47), restenosis (OR: 1.46; 95% CI: 1.15-1.84), amputation (OR: 1.83; 95% CI: 1.48-2.27), and amputation-free survival (OR: 2.29; 95% CI: 1.75-3.00). Preoperative NLR was more predictive than postoperative testing for mortality and restenosis.
Key findings
- High NLR was associated with mortality (OR: 1.31; 95% CI: 1.17-1.47) and restenosis (OR: 1.46; 95% CI: 1.15-1.84).
- High NLR was associated with amputation (OR: 1.83; 95% CI: 1.48-2.27) and amputation-free survival (OR: 2.29; 95% CI: 1.75-3.00).
- Preoperative NLR testing was more valuable than postoperative testing for predicting mortality and restenosis.
- High PLR was not significantly associated with mortality, restenosis, or amputation; high SII was not significantly associated with restenosis.
Why it matters
These pooled findings suggest that NLR may help identify patients with LEASO at greater risk of adverse outcomes, with preoperative measurement potentially offering more prognostic information for mortality and restenosis. The results also distinguish NLR from other indices, for which associations were less consistent. Such prognostic information may support risk assessment, although the evidence does not establish that acting on these measures improves outcomes.
What to keep in mind
The review pooled findings from 33 studies, and the abstract does not report study-level design or quality details; the evidence therefore supports prognostic associations rather than causal conclusions.