Isopropyl Alcohol-Induced Peripheral Neuropathy After Transdermal Exposure: A Case Report.

J Pharm PractJan 11, 2026 (epub)
Case ReportNeurology

Jack Shapiro, Thomas Cranmer, Emma Formaro et al.

✦ AI-curated · Sources linked

Case in brief

An 80-year-old man developed numbness in his left lower extremity after applying isopropyl alcohol topically several times daily for pain relief over 3 months. After other diagnoses were ruled out, the neuropathy was attributed to transdermal isopropyl alcohol exposure. He stopped using it, and the numbness completely resolved after 3 weeks.

What made this case unusual

The reported neuropathy followed repeated dermal exposure rather than the better-documented ingestion-related isopropyl alcohol toxicity.

Diagnostic / clinical pearl

When evaluating peripheral neuropathy, ask about repeated topical chemical exposures as well as ingestion and other toxic exposures.

Source

PubMed · PMID 41521653

Published in J Pharm Pract. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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