Results from the Multicenter Nonrandomized BREAST-II Trial for Total Breast Reconstruction Solely Using Autologous Fat Transfer: 1-Year Follow-Up.
Wessel B W van der Venne, Kyrah S Goeree, Jamilla L M Wederfoort et al.
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In 30 seconds
This multicenter, nonrandomized clinical trial evaluated total breast reconstruction using autologous fat transfer (AFT) with external expansion in women with a history of or planned mastectomy at 8 Dutch hospitals. Among 229 women followed for 12 months, BREAST-Q measures improved, including Satisfaction with Chest (+17.22 ± 27.27; P < 0.001). Across 805 AFT sessions, 52 adverse events were reported, a complication rate of 6.46%; hospital stays were less than 1 day per session. The findings indicate improved patient-reported outcomes alongside reported procedural complications.
Key findings
- At 12 months, Satisfaction with Chest increased by +17.22 ± 27.27 (P < 0.001).
- Psychosocial Well-Being, Sexual Well-Being, and Physical Well-Being: Chest also improved significantly (all P < 0.001).
- BODY-Q satisfaction scores increased for the abdomen, back, body, hips/outer thighs, inner thighs, and scars (all P < 0.001).
- There were 52 adverse events among 805 AFT sessions (6.46% complication rate); hospital stays were less than 1 day per session.
Why it matters
The study adds multicenter 12-month evidence on patient-reported outcomes and safety for AFT as a total reconstruction approach after mastectomy. Improvements across breast-related and body-related satisfaction measures may help inform discussions of reconstruction options, while the reported adverse events underscore the need to consider procedural risks.
What to keep in mind
The trial was nonrandomized, and the reported follow-up was limited to 12 months.