Acceptance and the willingness to pay for human papilloma virus (HPV) vaccine: A systematic review.
Soheila Rajaie, Sara Emamgholipour, Samad Azari et al.
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In 30 seconds
This systematic review synthesised evidence published from 2015 to 2025 on HPV vaccine knowledge, acceptance, attitudes, and willingness to pay (WTP) across populations worldwide. Searches identified 35 studies, with the largest contributions from China and Nigeria. Reported WTP ranged from 52.68% in lower-middle-income countries to 65.38% in low-income countries; mean WTP was highest in upper-middle-income settings. Knowledge, positive attitudes, socioeconomic status, and trust were associated with greater WTP, while cost was the primary reported barrier.
Key findings
- Across included studies, WTP ranged from 52.68% in lower-middle-income countries to 65.38% in low-income countries.
- Mean WTP was highest in upper-middle-income settings.
- Knowledge, positive attitudes, socioeconomic status, and trust were associated with higher WTP; cost was the primary barrier.
Why it matters
HPV vaccine uptake depends not only on vaccine effectiveness but also on public acceptance and affordability. The review highlights cost and differences in knowledge, attitudes, and trust as factors relevant to willingness to pay across settings. These findings can inform consideration of access barriers and public-health strategies, while the variation between populations cautions against assuming a uniform response.
What to keep in mind
The review synthesised studies across diverse populations and settings; the abstract does not report pooled estimates or describe the comparability of included studies.