Biodegradable Stents in Benign Biliary and Pancreatic Disease: A Systematic Review.
Dimitra V Peristeri, Harriet Fransis, Ravi Vissapragada et al.
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In 30 seconds
This systematic review assessed human studies of biodegradable stents for benign biliary and pancreatic diseases, including strictures and bile leaks. Fifteen studies involving 467 patients were included; stents were placed endoscopically or percutaneously. Technical success was 99.4%, while clinical success was 73.3%. Complications included cholangitis, recurrent stricture, bleeding, and pain or fever. The mean reintervention rate was 35.5%, often reflecting planned care after stent degradation rather than device failure. The authors concluded that biodegradable stents appear safe and effective in selected conditions, while noting the need for prospective and randomized studies.
Key findings
- Across 15 studies and 467 patients, technical success was 99.4% and clinical success was 73.3%.
- The mean reintervention rate was 35.5% (range 0-100%), largely reflecting planned management after stent degradation.
- A total of 108 complications were reported; cholangitis was most frequent (n = 36), followed by stricture recurrence (n = 19).
Why it matters
Biodegradable stents offer temporary ductal support without planned retrieval, potentially addressing some burdens of conventional stenting. The review suggests high technical placement success, but the lower clinical success and substantial reintervention rate underscore that technical feasibility does not guarantee durable benefit. These findings help frame the evidence while highlighting the need to clarify which benign conditions and patients are most likely to benefit.
What to keep in mind
The evidence comprised 15 studies, and the authors call for prospective studies and randomized trials to establish optimal indications and long-term outcomes.