ENDOPHTHALMITIS INCIDENCE AFTER VITRECTOMY: A Systematic Review and Meta-Analysis of Risk Factors and Prevention Strategy.
RetinaSep 1, 2026
Clinical ResearchOphthalmology
Robert McGrath, Liam Mulcahy, Abdulrahman Al Abri et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the incidence of endophthalmitis after vitrectomy across 69 studies involving 1,979,160 procedures. The overall incidence was found to be 0.14%. The analysis revealed that non-fluid intraocular tamponade significantly reduced endophthalmitis rates, while prophylactic subconjunctival antibiotics did not show a benefit.
Key findings
- Endophthalmitis incidence after vitrectomy was 0.14%.
- 25-gauge instruments had a significantly higher endophthalmitis risk compared to 23-gauge (OR 2.03).
- Non-fluid intraocular tamponade was associated with significantly lower endophthalmitis rates (OR 0.15).
- Prophylactic subconjunctival antibiotics did not reduce endophthalmitis risk compared to topical antibiotics (OR 0.77).
Why it matters
Understanding the incidence and risk factors for endophthalmitis after vitrectomy is crucial for improving surgical outcomes. This study highlights effective strategies for minimizing this serious complication, which can impact patient vision and quality of life.