First Prospective, Single-Arm, Multicenter Study to Evaluate the Safety and Efficacy of the Overall Thrombectomy System for Stroke: iNedit, iNdeep, and iNtercept in Patients with Acute Ischemic Stroke (SEMTiC-01 Study).
AJNR Am J NeuroradiolSep 2, 2026 (epub)
Oscar Chirife, Guillem Dolz, Fernando Delgado et al.
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In 30 seconds
The SEMTiC-01 study is a prospective, multicenter, single-arm trial evaluating the safety and efficacy of a novel neurothrombectomy system in 175 patients with acute ischemic stroke due to large vessel occlusion. Successful reperfusion was achieved in 75.4% of patients, indicating the system's effectiveness in this population.
Key findings
- Successful reperfusion was achieved in 75.4% of the intention-to-treat population.
- Good functional outcomes (mRS 0-2) were observed in 55.8% of patients at 90 days.
- Symptomatic intracranial hemorrhage occurred in 1.7% of patients.
- Device navigability was rated good in over 75% of cases.
Why it matters
This study provides evidence for a new thrombectomy system that may enhance reperfusion rates and functional outcomes in patients with acute ischemic stroke, which is critical for improving patient care in emergency settings.