Surgical treatment of Peyronie's disease by plaque incision and buccal mucosa graft: a systematic review and meta-analysis.
Hattan Badr, Carlo Bettocchi, Abdulrahman Alsalem et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis assessed plaque incision with buccal mucosa grafting for Peyronie’s disease, using 17 reports (nine full-text studies and eight abstracts). Pooled results indicated a 98.6% success rate and 92.1% satisfaction rate. De novo erectile dysfunction and penile shortening were reported at 1.7% and 1.1%, respectively. Erectile-function scores and length of the affected penile side also increased. In head-to-head analyses, outcomes were comparable with other grafting methods; the authors note that randomized trials are needed for further evaluation.
Key findings
- Pooled success and satisfaction rates with plaque incision and buccal mucosa grafting were 98.6% and 92.1%, respectively.
- De novo erectile dysfunction was reported in 1.7%, and penile shortening in 1.1%.
- The International Index of Erectile Function increased by 1.69 points, and affected-side length increased by 1.99 cm.
- Head-to-head analyses found outcomes comparable between buccal mucosa and other grafting methods.
Why it matters
The pooled findings suggest that plaque incision with buccal mucosa grafting can achieve high reported success and satisfaction, with low reported rates of erectile dysfunction and shortening. Comparisons with other grafts did not show a clear advantage for this technique, so the results help frame it as a potential surgical option rather than establishing its superiority.
What to keep in mind
The review included reports and abstracts, and the authors state that further randomized clinical trials are needed to evaluate efficacy against other grafting techniques.