Acute Promyelocytic Leukemia with t(11;17)(q23.2;q21.2) Treated with Haploidentical Transplantation Using Post-transplant Cyclophosphamide.

Intern MedMar 3, 2026 (epub)
Case ReportHematologyOncology (Medical)

Yujiro Ito, Ayato Sumioka, Ibuki Takatsuka et al.

✦ AI-curated · Sources linked

Case in brief

A 55-year-old man presented with acute promyelocytic leukemia (APL), diagnosed from its distinctive morphology. Subsequent cytogenetic testing identified t(11;17)(q23.2;q21.2), suggesting a ZBTB16::RARA fusion. After conventional chemotherapy, he underwent haploidentical transplantation with post-transplant cyclophosphamide and maintained long-term remission.

What made this case unusual

The leukemia had the atypical t(11;17)(q23.2;q21.2) translocation rather than the more common t(15;17), with the fusion gene suggested by cytogenetic findings.

Diagnostic / clinical pearl

Distinctive morphology can support an APL diagnosis even when cytogenetic testing later reveals an atypical translocation; cytogenetic characterization can refine the diagnostic picture.

Source

PubMed · PMID 41780979

Published in Intern Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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