Euglycemic Diabetic Ketoacidosis Following Treatment with Tirzepatide and SGLT-2 Inhibitors: A Case Report and Literature Review.

Intern MedMar 17, 2026 (epub)
Case ReportEndocrinologyInternal Medicine (General)

Toshitaka Sawamura, Shigehiro Karashima, Ai Ohmori et al.

✦ AI-curated · Sources linked

Case in brief

A patient receiving tirzepatide and an SGLT-2 inhibitor developed euglycemic diabetic ketoacidosis while continuing both medications during a sick-day condition. The report highlights appetite loss as a relevant concern with tirzepatide and the potential for EDKA in the setting of SGLT-2 inhibitor use. After the sick-day condition resolved, both agents were reintroduced successfully, with no adverse effects reported.

What made this case unusual

EDKA occurred while the patient continued both tirzepatide and an SGLT-2 inhibitor during a sick-day condition; both medications were later reintroduced without reported adverse effects.

Diagnostic / clinical pearl

During sick-day conditions, consider EDKA in patients taking SGLT-2 inhibitors, particularly when appetite loss accompanies continued tirzepatide use.

Source

PubMed · PMID 41850834

Published in Intern Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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