CL16019, A Combination of Cissus quadrangularis and Boswellia serrata Extracts Promotes the Healing of Distal Radius Fractures: A Multicentric, Randomized, Open-Label Study.
Anjaneya Venkata Vara Prasad Mungara, Nawazish Rabbani Shaik, Chandra Kiran M et al.
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In 30 seconds
This multicentre, randomized, open-label study evaluated CL16019, a combination of Cissus quadrangularis and Boswellia serrata extracts, alongside standard treatment for distal radius fractures. Fifty adults aged 30–50 years with type I, IIA, or IIB fractures were assigned equally to standard treatment alone or standard treatment plus CL16019 for 60 days. At trial end, mean Radius Union Scoring System scores were 5.54 ± 1.77 with standard treatment and 7.96 ± 0.20 with CL16019 added (p < 0.0001). The supplemented group also had declines in pain and wrist-function questionnaire scores.
Key findings
- At trial end, RUSS scores were 5.54 ± 1.77 with standard treatment and 7.96 ± 0.20 with standard treatment plus CL16019 (p < 0.0001).
- The CL16019 group had significant declines in visual analog scale and Patient-Rated Wrist Evaluation Questionnaire scores (p < 0.05).
- Physician and subject global assessment scores were higher in the standard-treatment-plus-CL16019 group.
Why it matters
Fracture union and recovery of wrist symptoms and function are clinically relevant outcomes after distal radius fracture. This trial reports better radiographic healing scores and improvements in symptom and wrist-function measures when the herbal formulation was added to standard treatment. The findings provide preliminary clinical evidence for an adjunctive approach, while the open-label design and limited study population warrant cautious interpretation.
What to keep in mind
The study was open-label and included 50 participants aged 30–50 years with specified fracture types, limiting the population to which the findings directly apply.