An Enhanced Treatment Algorithm Targeting Mucosal Healing Is Effective and Safe in Older Patients With Crohn's Disease: A Post Hoc Analysis of the REACT2 Trial.
Shane W Goodwin, Sudheer Kumar Vuyyuru, Rocio Sedano et al.
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In 30 seconds
This post hoc analysis of the randomized REACT2 trial examined whether age modified the effect of enhanced-care versus step-care algorithms in patients with Crohn’s disease. Practices had been randomized to the two treatment strategies, and investigators assessed Crohn’s-related complications by 24 months using regression analyses. The abstract reports no difference in treatment between younger and older patients at 24 months. It concludes that enhanced-care was effective in older patients and was not associated with increased risk compared with step-care. No quantitative effect estimate is provided.
Key findings
- At 24 months, the abstract reports no difference in treatment between younger and older patients.
- In older patients, enhanced-care was effective and was not associated with increased risk compared with step-care.
Why it matters
Older adults with Crohn’s disease may have distinct safety considerations when treatment is intensified toward mucosal healing. This analysis offers evidence from a randomized trial framework that an enhanced-care algorithm was not associated with greater risk than step-care in this group, while the abstract provides no numerical estimates to quantify the effect.
What to keep in mind
This was a post hoc analysis, and the abstract provides no sample size or quantitative effect estimates.