Temporal Net Water Uptake Evolution and Its Association with Functional Outcome in Acute Ischemic Stroke.
AJNR Am J NeuroradiolOct 1, 2026 (epub)
Wiktor Olszewski, Fabiano Cavalcante, Laura van Poppel et al.
✦ AI-curated · Sources linked
In 30 seconds
This multicenter randomized controlled trial examined the relationship between temporal changes in net water uptake (NWU) and functional outcomes in 115 patients with acute ischemic stroke. The study found that NWU at 1 week post-stroke was significantly associated with functional dependence at 90 days, with an adjusted odds ratio of 0.66 per 5-percentage-point increase in NWU.
Key findings
- Median NWU increased from 4.3% at baseline to 15% at 1 week.
- NWU at 1 week was significantly associated with functional dependence, aOR 0.66 per 5% increase.
- A higher increase in NWU from baseline to 1 week was also linked to functional dependence, aOR 0.66 per 5% increase.
Why it matters
Understanding the evolution of NWU in the first week after an acute ischemic stroke can help clinicians identify patients at risk for poor functional outcomes, potentially guiding secondary treatment strategies.