Discontinuation of Dialysis After ¹⁷⁷Lu-PSMA Therapy in mCRPC With Malignant Obstructive Uropathy.

Clin Nucl MedMar 24, 2026 (epub)
Case ReportUrologyOncology (Medical)Nephrology

Enes Yerdes, Ebuzer Kalender

✦ AI-curated · Sources linked

Case in brief

A patient with metastatic castration-resistant prostate cancer developed malignant obstructive uropathy, leading to post-renal acute kidney injury and dialysis-dependent renal failure. After ¹⁷⁷Lu-PSMA radioligand therapy, imaging showed marked tumor regression, and the patient was able to discontinue dialysis.

What made this case unusual

The case links marked tumor regression after ¹⁷⁷Lu-PSMA therapy with dialysis discontinuation in a patient whose advanced prostate cancer had caused malignant obstructive uropathy and dialysis-dependent renal failure.

Diagnostic / clinical pearl

In this reported case, malignant obstructive uropathy from mCRPC was associated with dialysis-dependent renal failure; tumor regression after ¹⁷⁷Lu-PSMA therapy coincided with dialysis discontinuation.

Source

PubMed · PMID 41940836

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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