Malignant Melanoma With Rhabdomyosarcomatous Differentiation: Report of 2 New Cases.
Maged Daruish, Hazem Ibrahim
✦ AI-curated · Sources linked
Case in brief
The report describes two cases of primary cutaneous malignant melanoma with rhabdomyosarcomatous differentiation. Histological examination identified divergent skeletal-muscle differentiation, including rhabdoid morphology, creating a diagnostic challenge. The authors emphasize thorough sampling and skeletal muscle immunostains to support accurate diagnosis. The abstract characterizes this melanoma variant as aggressive but does not provide further clinical details or outcomes.
What made this case unusual
The melanomas showed rhabdomyosarcomatous differentiation, an uncommon divergent differentiation that can complicate recognition of the primary cutaneous melanoma.
Diagnostic / clinical pearl
When a cutaneous melanoma shows rhabdoid morphology, thorough histological sampling and skeletal muscle immunostains can help identify rhabdomyosarcomatous differentiation.