A Case of Incidental Adenoid Cystic Carcinoma of the Trachea on Gallium-68 PSMA PET/CT Imaging.

Clin Nucl MedApr 2, 2026 (epub)
Case ReportOncology (Medical)Radiology (Diagnostic)Pathology (Anatomic & Clinical)

Safiya Sabuncu, Savaş Karyağar, Ekrem Cengiz Seyhan et al.

✦ AI-curated · Sources linked

Case in brief

A 66-year-old man with biopsy-proven prostate adenocarcinoma and a PSA of 16 ng/mL underwent gallium-68 PSMA PET/CT for staging. Imaging showed focal uptake in the mid-prostate, predominantly on the left, consistent with the known malignancy. It also revealed intense PSMA uptake in a polypoid lesion within the tracheal lumen. Histopathological examination identified the tracheal lesion as adenoid cystic carcinoma.

What made this case unusual

The staging scan for prostate cancer incidentally detected a PSMA-avid tracheal lesion that proved to be a separate primary malignancy, adenoid cystic carcinoma.

Diagnostic / clinical pearl

PSMA uptake is not specific to prostate cancer; an unexpected PSMA-avid lesion may require evaluation for a nonprostatic tumor.

Source

PubMed · PMID 41954949

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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