A Rare Case of Cutaneous Extramedullary Hematopoiesis in Chronic Myeloid Leukemia.

J Cutan PatholApr 10, 2026 (epub)
Case ReportHematologyOncology (Medical)Open access

Bennett Christie-Nguyen, Hanadi El Achi, Levani Iashvili et al.

✦ AI-curated · Sources linked

Case in brief

A 34-year-old Hispanic man presented with multiple bilateral lower-extremity skin lesions, right buttock and leg pain, fatigue, and splenomegaly; evaluation identified chronic-phase chronic myeloid leukemia (CML). Skin biopsy showed dermal infiltration by maturing granulocytes, megakaryocytes, and erythroid precursors. FISH confirmed BCR::ABL1 in the neoplastic extramedullary hematopoietic infiltrate, supporting cutaneous extramedullary hematopoiesis (CEH). After initial hydroxyurea and dasatinib, treatment was changed to imatinib once chronic-phase CML was confirmed. B symptoms resolved, white blood cell counts normalized, and leg swelling decreased.

What made this case unusual

The skin lesions represented BCR::ABL1-positive CEH in chronic-phase CML, an exceedingly rare site of extramedullary hematopoiesis in this disease.

Diagnostic / clinical pearl

In a patient with CML and skin lesions, histopathology and immunohistochemical analysis, supported by molecular testing, can help distinguish CEH from blast-phase CML or myeloid sarcoma.

Source

PubMed · PMID 41963109Free full text on PubMed Central

Published in J Cutan Pathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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