Mechanism and clinical application of ozone therapy in treating skin ulcer diseases.

In 30 seconds

This systematic review examined proposed mechanisms and clinical research on ozone therapy for skin ulcer diseases, including diabetic foot ulcers and burns. It describes potential effects on antimicrobial activity, tissue oxygenation, circulation, immune function, and tissue repair, and reports that ozone therapy has shown efficacy with safety described as generally controllable. The review identifies ozone concentration as a key focus of existing research but provides no pooled effect estimate or other quantitative clinical result in the abstract. It concludes that more rigorous clinical studies are needed to refine treatment approaches and develop standard guidelines.

Key findings

• The review describes ozone therapy as having antimicrobial and broader biological effects, including improved tissue oxygenation, circulation, and tissue repair.
• Clinical research reviewed reports efficacy for diabetic foot ulcers and other skin ulcer conditions, with safety characterized as controllable.
• Existing research has focused substantially on the relationship between ozone concentration and therapeutic efficacy.

Why it matters

Skin ulcers can involve impaired circulation, infection, and delayed repair, and the review outlines how ozone therapy might affect several of these processes. Its reported clinical promise may warrant further evaluation, but the abstract provides no quantitative estimate of benefit and highlights unresolved questions about optimal concentrations, application methods, long-term safety, and which ulcers respond best.

What to keep in mind

The abstract reports no pooled quantitative results and identifies a need for more rigorous clinical research. Optimal concentrations and application methods, long-term comparative efficacy and safety, and ulcer types most likely to respond remain unresolved.