Endometrial Gastrointestinal Mucinous Metaplasia With Goblet Cells and KRAS Mutation-Report of Two Patients and Review of Literature.
Stephanie Barak, Padmini A Manrai, M Ruhul Quddus
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Case in brief
Two postmenopausal patients presented with endometrial polyps exhibiting gastrointestinal mucinous metaplasia characterized by goblet cells. Molecular analysis revealed KRAS mutations in both patients, with mutations located in codons 12/13 in the first patient and codon 61 in the second. These findings suggest a potential link between gastrointestinal metaplasia and early endometrial carcinogenesis.
Diagnostic / clinical pearl
Clinicians should consider the presence of gastrointestinal mucinous metaplasia in endometrial polyps as a potential precursor lesion, especially in postmenopausal patients.
Why it matters
The identification of KRAS mutations in benign endometrial polyps may indicate an early event in the pathway to endometrial carcinoma, highlighting the need for further investigation into the significance of these findings.