Systemic Therapies for the Treatment of Cutaneous Malignancies in Solid Organ Transplant Recipients.

Dermatol SurgApr 14, 2026 (epub)
Clinical ResearchOncology (Medical)Dermatology

Akshay Pulavarty, Derek Maas, Archie Spindler et al.

✦ AI-curated · Sources linked

Condensed from the publisher's abstract. An xxcode editorial summary of this publication has not been generated yet.

From the abstract

Solid organ transplant recipients (SOTRs) face frequent advanced cutaneous malignancies, yet data guiding systemic therapy are limited.

Reported results

Among 196 SOTRs treated with ICIs (101 cutaneous squamous cell carcinoma, 83 melanoma, 12 Merkel cell carcinoma), the overall response rate (ORR) was 39.3%, and lack of progression occurred in 58.0%. Graft rejection occurred in 36.9% and graft failure in 22.3%. A higher number of baseline immunosuppressive agents decreased odds of rejection (OR 0.55) and failure (OR 0.38).

Authors' conclusions

ICIs provide antitumor activity but substantial graft-related risk, while T-VEC and HPIs show high response rates with no reported rejection.

Source

PubMed · PMID 41990252

Published in Dermatol Surg. The text above is extracted from the publisher's own abstract and has not been edited by xxcode. For clinical decisions, review the original publication.

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