Severe Hypoglycemia Associated With High-Dose Methadone in a Patient With ESRD: A Case Report and Review.

Pain Manag NursApr 16, 2026 (epub)
Case ReportEndocrinologyInternal Medicine (General)Nephrology

Jay Patel, Emily Tyler, Jesse Burton et al.

✦ AI-curated · Sources linked

Case in brief

A 49-year-old man with end-stage renal disease on hemodialysis experienced severe hypoglycemia while on high-dose methadone. Laboratory tests indicated endogenous hyperinsulinemia as the underlying cause. Following a reduction in methadone dosage, the hypoglycemic episodes resolved completely without recurrence, emphasizing the importance of careful management in similar patients.

Diagnostic / clinical pearl

Clinicians should be vigilant for hypoglycemia in patients on high-dose methadone, especially those with renal impairment, and consider routine glucose monitoring.

Source

PubMed · PMID 41997776

Published in Pain Manag Nurs. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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