Kidney transplant outcomes in patients aged ≥ 70 years: a systematic review and meta-analysis of multicenter or registry-based studies with future directions and a multicenter study proposal.
Dionysios Prevezanos, Konstantinos Kossenas, Spyridon Vernadakis et al.
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In 30 seconds
This systematic review and meta-analysis examined kidney transplant outcomes in recipients aged ≥ 70 years, analyzing data from five multicenter studies with 272,982 participants. The study found that older recipients had lower overall survival (RR = 0.87) and 5-year survival (RR = 0.86) compared to those under 70, although graft survival rates were similar across age groups.
Key findings
- Recipients aged ≥ 70 years had lower overall survival compared to those < 70 years (RR = 0.87).
- Five-year survival was also lower in recipients aged ≥ 70 years (RR = 0.86).
- No significant differences in overall graft survival or early graft-related outcomes were observed between age groups.
- Substantial heterogeneity was noted for long-term outcomes.
Why it matters
Understanding the impact of age on kidney transplant outcomes is crucial for clinicians to make informed decisions regarding patient selection and management, especially as the population ages.
What to keep in mind
The review included a limited number of studies and exhibited substantial heterogeneity in long-term outcomes.