Does Adherence Modify Low-Dose Aspirin Effects in Pregnancy? Post Hoc Analysis From a Multi-Centre Trial.
Musaku Mwenechanya, Abigail Mwapule Tembo, Elwyn Chomba et al.
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In 30 seconds
This post hoc analysis of a randomized controlled trial involving 11,908 women evaluated the impact of low-dose aspirin (LDA) on preterm delivery (PTD) and perinatal mortality, focusing on treatment initiation timing and adherence. Results indicated that neither the timing of LDA initiation nor adherence significantly modified the treatment effects, with risk ratios for PTD remaining stable at 0.97.
Key findings
- 85.5% of mothers had over 90% adherence to treatment.
- For each 1-week increase in gestational age at treatment initiation, the risk ratio for PTD was 0.97.
- For each 5% increase in adherence, the risk ratio for PTD remained at 1.01.
Why it matters
Understanding the effects of low-dose aspirin on preterm delivery and perinatal outcomes is crucial for optimizing treatment strategies in pregnancy. This study suggests that timing and adherence may not significantly influence these outcomes, which can inform clinical decision-making.