Incidence and predictors of surgical recurrence after primary ileocolic resection in Crohn ileitis: a systematic review and meta-analysis.
Inflamm Bowel DisSep 1, 2026
Anouck E G Haanappel, Eline M L van der Does de Willebois, Mahsoem Ali et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the incidence and predictors of surgical recurrence after primary ileocolic resection (ICR) in patients with Crohn disease. Analyzing data from 55 studies involving 28,354 patients, it found that the 5-year and 10-year surgical recurrence rates in the biologics era (post-2000) were 5.7% and 13.0%, respectively, indicating a significant decrease over time.
Key findings
- 5-year surgical recurrence rate in the biologics era is 5.7% (95% CI, 3.9-8.4).
- 10-year surgical recurrence rate in the biologics era is 13.0% (95% CI, 8.3-19.7).
- Surgical recurrence rates have decreased over the past decades but stabilized after 2000.
- No significant predictors for surgical recurrence were identified.
Why it matters
Understanding the trends in surgical recurrence rates after ileocolic resection for Crohn disease is crucial for clinicians to inform patients about their prognosis and to guide treatment strategies in the biologics era.