Comparative evaluation of oxidative stress biomarkers F2-isoprostanes and 8-OHdG in Parkinson's disease and Type 2 Diabetes Mellitus: a systematic review and meta-analysis of human studies.
Samwel Sylvester Msigwa, Maiko Charles Mkwambe, Qiu-Yan Yu et al.
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In 30 seconds
This systematic review and meta-analysis evaluated oxidative stress biomarkers F2-isoprostanes and 8-OHdG in individuals aged ≥ 50 years with Type 2 Diabetes Mellitus (T2DM) and Parkinson's Disease (PD). Among 7,521 participants, F2-isoprostanes and 8-OHdG were significantly elevated in T2DM (g = 1.60 and g = 2.64, respectively, p < 0.001), while only 8-OHdG showed a moderate increase in PD (g = 0.78, p = 0.011).
Key findings
- F2-isoprostanes were elevated in T2DM with a standardized difference of g = 1.60.
- 8-OHdG was significantly elevated in T2DM with a standardized difference of g = 2.64.
- In PD, 8-OHdG showed a moderate elevation with g = 0.78, while F2-isoprostanes were not significantly elevated.
- Extreme oxidative stress was observed in T2DM patients with nephropathy (g = 5.24).
Why it matters
Understanding the distinct oxidative stress profiles in T2DM and PD can help clinicians identify potential biomarkers for monitoring disease progression and comorbidities, ultimately guiding therapeutic strategies.
What to keep in mind
High heterogeneity in T2DM studies (I² > 90%) indicates methodological variability among included studies.