Hand, foot, and mouth disease: A systematic review of global evidence, climatic drivers, and research gaps (2000-2023).
Muhamad Nur Naim Ishak, Rahmat Dapari, Ahmad Norasidi Mohd Raffie et al.
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In 30 seconds
This systematic review analyzed 125 studies on hand, foot, and mouth disease (HFMD) from 2000 to 2023, primarily focusing on children under five. The research highlighted a concentration of studies in Asia, particularly China, Malaysia, and Singapore, and identified climatic factors like temperature and humidity as significant, while noting a lack of diverse methodological approaches and limited evaluation of intervention strategies.
Key findings
- 125 studies were included, mostly from China, Malaysia, and Singapore.
- Research predominantly focused on children under five years of age.
- Climatic factors, especially temperature and humidity, were frequently studied.
- Outcomes were mainly limited to incidence and outbreak counts.
Why it matters
Understanding the epidemiology and environmental drivers of HFMD is crucial for developing effective public health strategies. The findings underscore the need for broader research to inform policy and improve prevention efforts, particularly in underrepresented regions.