Childhood cognitive control as a predictor of long-term clinical and functional outcomes in Tourette syndrome.
J Child Psychol PsychiatryApr 21, 2026 (epub)
Kathryn E Barber, Emily J Ricketts, Douglas W Woods et al.
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In 30 seconds
This randomized controlled trial examined the role of childhood cognitive control in predicting long-term outcomes in 80 individuals with Tourette syndrome (TS). The study found that better childhood cognitive control, including inhibition and processing speed, was associated with lower tic severity and higher quality of life in early adulthood, with significant results maintained after adjusting for comorbidities.
Key findings
- Greater inhibition and processing speed in childhood predicted lower tic severity and impairment in early adulthood.
- Higher odds of tic remission were associated with better childhood cognitive control.
- Improved working memory and response flexibility correlated with higher educational attainment and income.
Why it matters
Understanding the predictors of long-term outcomes in Tourette syndrome can inform treatment strategies and interventions. Enhancing cognitive control in childhood may improve clinical and functional trajectories for individuals with TS.