Endoscopic Surveillance in Serrated Polyposis Syndrome, Two or Three-Year Intervals: A Non-inferiority Randomized Trial.
Dig Dis SciApr 21, 2026 (epub)
Jorge López-Vicente, Daniel Rodríguez-Alcalde, Luis Hernández Villalba et al.
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In 30 seconds
This multicenter, randomized non-inferiority trial evaluated the incidence of advanced neoplasia in patients with serrated polyposis syndrome undergoing colonoscopy surveillance at two- versus three-year intervals. Among 131 patients, the incidence of advanced neoplasia was 6.9% for the two-year group and 13.6% for the three-year group, with no statistical difference (p = 0.208).
Key findings
- Advanced neoplasia incidence was 6.9% in the 2-year group and 13.6% in the 3-year group.
- No colorectal cancer was detected among the resected lesions.
- The risk difference for advanced neoplasia was +6.7%, exceeding the non-inferiority margin.
- Diagnosis of serrated polyposis syndrome ≤3 years was associated with advanced neoplasia (OR 4.4).
Why it matters
Understanding the optimal surveillance interval for serrated polyposis syndrome is crucial for balancing cancer risk and healthcare resource utilization. This study provides insights into the safety of extending surveillance intervals.